Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population
ObjectiveTo investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.MethodsA total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1148047/full |
| _version_ | 1827921700598054912 |
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| author | Dongren Sun Dongren Sun Mingyu Song Mingyu Song Chang Zeng Hengshu Chen Hengshu Chen Jingyuan Zhang Jingyuan Zhang Fan Liu Fan Liu Shihang Luo Shihang Luo Qiao Liao Qiao Liao Yeqing Xiao Weiye Xu Danfeng Zeng Zheren Tan Zheren Tan Fafa Tian Fafa Tian Xia Huang |
| author_facet | Dongren Sun Dongren Sun Mingyu Song Mingyu Song Chang Zeng Hengshu Chen Hengshu Chen Jingyuan Zhang Jingyuan Zhang Fan Liu Fan Liu Shihang Luo Shihang Luo Qiao Liao Qiao Liao Yeqing Xiao Weiye Xu Danfeng Zeng Zheren Tan Zheren Tan Fafa Tian Fafa Tian Xia Huang |
| author_sort | Dongren Sun |
| collection | DOAJ |
| description | ObjectiveTo investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.MethodsA total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (VDR, CYP2R1, CYP24A1, and CYP27B1) were genotyped using the SNPscan™ multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.ResultsIn the dominant, recessive, and over-dominant models, no significant association was observed between the selected SNPs in the CYP24A1 and CYP2R1 genes and PSD. However, univariate and multivariate logistic regression analysis revealed that the CYP27B1 rs10877012 G/G genotype was associated with a decreased risk of PSD (OR: 0.41, 95% CI: 0.18–0.92, p = 0.030 and OR: 0.42, 95% CI: 0.18–0.98, p = 0.040, respectively). Furthermore, haplotype association analysis indicated that rs11568820-rs1544410-rs2228570-rs7975232-rs731236 CCGAA haplotype in the VDR gene was associated with a reduced risk of PSD (OR: 0.14, 95% CI: 0.03–0.65, p = 0.010), whereas no significant association was observed between haplotypes in the CYP2R1 and CYP24A1 genes and PSD.ConclusionOur findings suggest that the polymorphisms of VitD metabolic pathway genes VDR and CYP27B1 may be associated with PSD in patients with ischemic stroke. |
| first_indexed | 2024-03-13T04:31:12Z |
| format | Article |
| id | doaj.art-a66cfad923ff4577afd7b8456c777ba4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T04:31:12Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a66cfad923ff4577afd7b8456c777ba42023-06-19T14:40:19ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11480471148047Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke populationDongren Sun0Dongren Sun1Mingyu Song2Mingyu Song3Chang Zeng4Hengshu Chen5Hengshu Chen6Jingyuan Zhang7Jingyuan Zhang8Fan Liu9Fan Liu10Shihang Luo11Shihang Luo12Qiao Liao13Qiao Liao14Yeqing Xiao15Weiye Xu16Danfeng Zeng17Zheren Tan18Zheren Tan19Fafa Tian20Fafa Tian21Xia Huang22Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Hengyang Central Hospital, Hengyang, Hunan, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Critical Care Medicine, The First People’s Hospital of Huaihua, Huaihua, Hunan, ChinaObjectiveTo investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.MethodsA total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (VDR, CYP2R1, CYP24A1, and CYP27B1) were genotyped using the SNPscan™ multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.ResultsIn the dominant, recessive, and over-dominant models, no significant association was observed between the selected SNPs in the CYP24A1 and CYP2R1 genes and PSD. However, univariate and multivariate logistic regression analysis revealed that the CYP27B1 rs10877012 G/G genotype was associated with a decreased risk of PSD (OR: 0.41, 95% CI: 0.18–0.92, p = 0.030 and OR: 0.42, 95% CI: 0.18–0.98, p = 0.040, respectively). Furthermore, haplotype association analysis indicated that rs11568820-rs1544410-rs2228570-rs7975232-rs731236 CCGAA haplotype in the VDR gene was associated with a reduced risk of PSD (OR: 0.14, 95% CI: 0.03–0.65, p = 0.010), whereas no significant association was observed between haplotypes in the CYP2R1 and CYP24A1 genes and PSD.ConclusionOur findings suggest that the polymorphisms of VitD metabolic pathway genes VDR and CYP27B1 may be associated with PSD in patients with ischemic stroke.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1148047/fullvitamin Dpost-stroke depressionVDRCYP2R1CYP24A1CYP27B1 |
| spellingShingle | Dongren Sun Dongren Sun Mingyu Song Mingyu Song Chang Zeng Hengshu Chen Hengshu Chen Jingyuan Zhang Jingyuan Zhang Fan Liu Fan Liu Shihang Luo Shihang Luo Qiao Liao Qiao Liao Yeqing Xiao Weiye Xu Danfeng Zeng Zheren Tan Zheren Tan Fafa Tian Fafa Tian Xia Huang Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population Frontiers in Psychiatry vitamin D post-stroke depression VDR CYP2R1 CYP24A1 CYP27B1 |
| title | Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population |
| title_full | Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population |
| title_fullStr | Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population |
| title_full_unstemmed | Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population |
| title_short | Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population |
| title_sort | associations of vitamin d related single nucleotide polymorphisms with post stroke depression among ischemic stroke population |
| topic | vitamin D post-stroke depression VDR CYP2R1 CYP24A1 CYP27B1 |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1148047/full |
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