Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy
Despite the worldwide acceptance of acetaminophen (APAP) as a necessary medicine in pediatrics, evidence that early exposure to APAP causes neurodevelopmental injury in susceptible babies and children has been mounting for over a decade. The evidence is diverse and includes extensive work with labor...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2024-03-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2022-01319.pdf |
| _version_ | 1797272435520700416 |
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| author | Lisa Zhao John P. Jones III Lauren G. Anderson Zacharoula Konsoula Cynthia D. Nevison Kathryn J. Reissner William Parker |
| author_facet | Lisa Zhao John P. Jones III Lauren G. Anderson Zacharoula Konsoula Cynthia D. Nevison Kathryn J. Reissner William Parker |
| author_sort | Lisa Zhao |
| collection | DOAJ |
| description | Despite the worldwide acceptance of acetaminophen (APAP) as a necessary medicine in pediatrics, evidence that early exposure to APAP causes neurodevelopmental injury in susceptible babies and children has been mounting for over a decade. The evidence is diverse and includes extensive work with laboratory animals, otherwise unexplained associations, factors associated with APAP metabolism, and limited studies in humans. Although the evidence has reached an overwhelming level and was recently reviewed in detail, controversy persists. This narrative review evaluates some of that controversy. Evidence from the pre- and postpartum periods was considered to avoid controversy raised by consideration of only limited evidence of risks during the prepartum period. Among other issues, the association between APAP use and the prevalence of neurodevelopmental disorders was considered. A systematic review revealed that the use of APAP in the pediatric population was never tracked carefully; however, historical events that affected its use were documented and are sufficient to establish apparent correlations with changes in the prevalence of neurodevelopmental disorders. Moreover, problems with the exclusive reliance on results of meta-analyses of large datasets with limited time frames of drug exposure were reviewed. Furthermore, the evidence of why some children are susceptible to APAPinduced neurodevelopmental injuries was examined. We concluded that available evidence demonstrates that early exposure to APAP causes neurodevelopmental injury in susceptible babies and small children. |
| first_indexed | 2024-03-07T14:29:18Z |
| format | Article |
| id | doaj.art-a66d0b2c028b49ccbf42dd1741f63bf7 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-03-07T14:29:18Z |
| publishDate | 2024-03-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-a66d0b2c028b49ccbf42dd1741f63bf72024-03-06T05:28:02ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482024-03-0167312613910.3345/cep.2022.0131920125555632Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversyLisa Zhao0John P. Jones III1Lauren G. Anderson2Zacharoula Konsoula3Cynthia D. Nevison4Kathryn J. Reissner5William Parker6 WPLab, Inc., Durham, NC, USA WPLab, Inc., Durham, NC, USA WPLab, Inc., Durham, NC, USA WPLab, Inc., Durham, NC, USA Institute for Arctic and Alpine Research, University of Colorado Boulder, Boulder, CO, USA Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC, USA WPLab, Inc., Durham, NC, USADespite the worldwide acceptance of acetaminophen (APAP) as a necessary medicine in pediatrics, evidence that early exposure to APAP causes neurodevelopmental injury in susceptible babies and children has been mounting for over a decade. The evidence is diverse and includes extensive work with laboratory animals, otherwise unexplained associations, factors associated with APAP metabolism, and limited studies in humans. Although the evidence has reached an overwhelming level and was recently reviewed in detail, controversy persists. This narrative review evaluates some of that controversy. Evidence from the pre- and postpartum periods was considered to avoid controversy raised by consideration of only limited evidence of risks during the prepartum period. Among other issues, the association between APAP use and the prevalence of neurodevelopmental disorders was considered. A systematic review revealed that the use of APAP in the pediatric population was never tracked carefully; however, historical events that affected its use were documented and are sufficient to establish apparent correlations with changes in the prevalence of neurodevelopmental disorders. Moreover, problems with the exclusive reliance on results of meta-analyses of large datasets with limited time frames of drug exposure were reviewed. Furthermore, the evidence of why some children are susceptible to APAPinduced neurodevelopmental injuries was examined. We concluded that available evidence demonstrates that early exposure to APAP causes neurodevelopmental injury in susceptible babies and small children.http://www.e-cep.org/upload/pdf/cep-2022-01319.pdfacetaminophenautismneurodevelopmentparacetamol |
| spellingShingle | Lisa Zhao John P. Jones III Lauren G. Anderson Zacharoula Konsoula Cynthia D. Nevison Kathryn J. Reissner William Parker Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Clinical and Experimental Pediatrics acetaminophen autism neurodevelopment paracetamol |
| title | Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy |
| title_full | Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy |
| title_fullStr | Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy |
| title_full_unstemmed | Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy |
| title_short | Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy |
| title_sort | acetaminophen causes neurodevelopmental injury in susceptible babies and children no valid rationale for controversy |
| topic | acetaminophen autism neurodevelopment paracetamol |
| url | http://www.e-cep.org/upload/pdf/cep-2022-01319.pdf |
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