Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures
ABSTRACT This study evaluated the performance and clinical utility of performing intravascular catheter tip cultures (CTC). A retrospective chart review was conducted over a 2.5 year period on all patients who demonstrated growth of at least one organism on CTC. There were a total of 391 CTC perform...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-12-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.04022-22 |
| _version_ | 1828263149440073728 |
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| author | Patrizia Ulrich Alexander J. Lepak Derrick J. Chen |
| author_facet | Patrizia Ulrich Alexander J. Lepak Derrick J. Chen |
| author_sort | Patrizia Ulrich |
| collection | DOAJ |
| description | ABSTRACT This study evaluated the performance and clinical utility of performing intravascular catheter tip cultures (CTC). A retrospective chart review was conducted over a 2.5 year period on all patients who demonstrated growth of at least one organism on CTC. There were a total of 391 CTC performed. 88 (23%) grew at least one organism, while 303 (77%) had no growth. Of the positive CTC, 81 (92%) had blood cultures (BC) collected within 14 days, whereas 7 (8%) did not. Of the positive CTC with BC, 67 (83%) were BC-positive, whereas 14 (17%) were negative. For cases with growth on both CTC and BC, the organisms identified were concordant for 46 (69%) cases and discordant for 21 (31%). Of the concordant cases, 43 (93%) were clinically considered to be bacterial bloodstream infections that were secondary to a catheter infection. For all of the positive CTC cases total, there was no change in the antibiotics or management, with the exceptions of 2 out of 88 (2%) cases. Catheters were removed and cultured for an average of 38.6 h (range: −98 to 288 h) after positive BC results were available. Most CTC are negative, and for the CTC that are positive, most are concordant with BC results. CTC results are generally only available several days after positive BC results are known. The CTC results did not alter the antibiotic therapy or management, with the exceptions of rare cases. As such, this study concludes that CTC do not contribute diagnostic or therapeutic value. Therefore, current guidelines by the Infectious Diseases Society of America on catheter-related bloodstream infection diagnosis should be revised to exclude CTC collection. IMPORTANCE In patients with intravascular catheters who are febrile or have positive blood cultures and no other obvious sources of infection, catheter tip cultures are often obtained to evaluate potential catheter-related bloodstream infections. However, previous studies reported that the management of catheter-related bloodstream infection cases is entirely based on blood culture growth and susceptibilities and that catheter tip cultures have low diagnostic positive predictive value. Our study represents the largest contemporary evaluation that includes chart reviews on all positive catheter tip culture cases. We found that positive cultures led to no changes in antibiotics or management, except for in two cases. Furthermore, 92% of positive catheter tip cultures were associated with blood culture collections, and catheter cultures were generally available only several days after the blood culture results were known. Thus, our study supports the claim that positive catheter tip cultures add limited diagnostic and therapeutic value in suspected catheter-related bloodstream infections. |
| first_indexed | 2024-04-13T04:06:49Z |
| format | Article |
| id | doaj.art-a66ffd9be0bd40948f10e1fa1a361864 |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-04-13T04:06:49Z |
| publishDate | 2022-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-a66ffd9be0bd40948f10e1fa1a3618642022-12-22T03:03:13ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972022-12-0110610.1128/spectrum.04022-22Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip CulturesPatrizia Ulrich0Alexander J. Lepak1Derrick J. Chen2UW Health, Madison, Wisconsin, USAUW Health, Madison, Wisconsin, USAUW Health, Madison, Wisconsin, USAABSTRACT This study evaluated the performance and clinical utility of performing intravascular catheter tip cultures (CTC). A retrospective chart review was conducted over a 2.5 year period on all patients who demonstrated growth of at least one organism on CTC. There were a total of 391 CTC performed. 88 (23%) grew at least one organism, while 303 (77%) had no growth. Of the positive CTC, 81 (92%) had blood cultures (BC) collected within 14 days, whereas 7 (8%) did not. Of the positive CTC with BC, 67 (83%) were BC-positive, whereas 14 (17%) were negative. For cases with growth on both CTC and BC, the organisms identified were concordant for 46 (69%) cases and discordant for 21 (31%). Of the concordant cases, 43 (93%) were clinically considered to be bacterial bloodstream infections that were secondary to a catheter infection. For all of the positive CTC cases total, there was no change in the antibiotics or management, with the exceptions of 2 out of 88 (2%) cases. Catheters were removed and cultured for an average of 38.6 h (range: −98 to 288 h) after positive BC results were available. Most CTC are negative, and for the CTC that are positive, most are concordant with BC results. CTC results are generally only available several days after positive BC results are known. The CTC results did not alter the antibiotic therapy or management, with the exceptions of rare cases. As such, this study concludes that CTC do not contribute diagnostic or therapeutic value. Therefore, current guidelines by the Infectious Diseases Society of America on catheter-related bloodstream infection diagnosis should be revised to exclude CTC collection. IMPORTANCE In patients with intravascular catheters who are febrile or have positive blood cultures and no other obvious sources of infection, catheter tip cultures are often obtained to evaluate potential catheter-related bloodstream infections. However, previous studies reported that the management of catheter-related bloodstream infection cases is entirely based on blood culture growth and susceptibilities and that catheter tip cultures have low diagnostic positive predictive value. Our study represents the largest contemporary evaluation that includes chart reviews on all positive catheter tip culture cases. We found that positive cultures led to no changes in antibiotics or management, except for in two cases. Furthermore, 92% of positive catheter tip cultures were associated with blood culture collections, and catheter cultures were generally available only several days after the blood culture results were known. Thus, our study supports the claim that positive catheter tip cultures add limited diagnostic and therapeutic value in suspected catheter-related bloodstream infections.https://journals.asm.org/doi/10.1128/spectrum.04022-22catheter culturecentral line-associated bloodstream infectioncatheter-related bloodstream infectioncatheterdifferential time to positivity |
| spellingShingle | Patrizia Ulrich Alexander J. Lepak Derrick J. Chen Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures Microbiology Spectrum catheter culture central line-associated bloodstream infection catheter-related bloodstream infection catheter differential time to positivity |
| title | Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures |
| title_full | Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures |
| title_fullStr | Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures |
| title_full_unstemmed | Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures |
| title_short | Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures |
| title_sort | diagnostic and therapeutic utility of positive intravascular catheter tip cultures |
| topic | catheter culture central line-associated bloodstream infection catheter-related bloodstream infection catheter differential time to positivity |
| url | https://journals.asm.org/doi/10.1128/spectrum.04022-22 |
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