Screening for HTLV-1 infection should be expanded in Europe
Human T-cell lymphotropic virus type 1 (HTLV-1) infection is spreading globally at an uncertain speed. Sexual, mother-to-child, and parenteral exposure are the major transmission routes. Neither vaccines nor antivirals have been developed to confront HTLV-1, despite infecting over 10 million people...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122400016X |
| _version_ | 1797302489612025856 |
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| author | Vicente Soriano Carmen de Mendoza |
| author_facet | Vicente Soriano Carmen de Mendoza |
| author_sort | Vicente Soriano |
| collection | DOAJ |
| description | Human T-cell lymphotropic virus type 1 (HTLV-1) infection is spreading globally at an uncertain speed. Sexual, mother-to-child, and parenteral exposure are the major transmission routes. Neither vaccines nor antivirals have been developed to confront HTLV-1, despite infecting over 10 million people globally and causing life-threatening illnesses in 10% of carriers. It is time to place this long-neglected disease firmly into the 2030 elimination agenda. Current evidence supports once-in-life testing for HTLV-1, as recommended for HIV, hepatitis B and C, along with targeted screening of pregnant women, blood donors, and people who attended clinics for sexually transmitted infections (STIs). Similar targeted screening strategies are already being performed for Chagas disease in some Western countries in persons from Latin America. Given the high risk of rapid-onset HTLV-1-associated myelopathy, universal screening of solid organ donors is warranted. To minimize organ wastage, however, the specificity of HTLV screening tests must be improved. HTLV screening of organ donors in Europe has become mandatory in Spain and the United Kingdom. The advent of HTLV point-of-care kits would facilitate testing. Finally, increasing awareness of HTLV-1 will help those living with HTLV-1 to be tested, clinically monitored, and informed about transmission-preventive measures. |
| first_indexed | 2024-03-07T23:39:36Z |
| format | Article |
| id | doaj.art-a66ffe6c91404330ac7ea3b4324ba95a |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-07T23:39:36Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a66ffe6c91404330ac7ea3b4324ba95a2024-02-20T04:18:55ZengElsevierInternational Journal of Infectious Diseases1201-97122024-03-0114099101Screening for HTLV-1 infection should be expanded in EuropeVicente Soriano0Carmen de Mendoza1Helath Sciences School & Medical Center, Inernational University of La Rioja (UNIR), Madrid, Spain; Corresponding author.Department of Internal Medicine, Puerta de Hierro University Hospital, Madrid, SpainHuman T-cell lymphotropic virus type 1 (HTLV-1) infection is spreading globally at an uncertain speed. Sexual, mother-to-child, and parenteral exposure are the major transmission routes. Neither vaccines nor antivirals have been developed to confront HTLV-1, despite infecting over 10 million people globally and causing life-threatening illnesses in 10% of carriers. It is time to place this long-neglected disease firmly into the 2030 elimination agenda. Current evidence supports once-in-life testing for HTLV-1, as recommended for HIV, hepatitis B and C, along with targeted screening of pregnant women, blood donors, and people who attended clinics for sexually transmitted infections (STIs). Similar targeted screening strategies are already being performed for Chagas disease in some Western countries in persons from Latin America. Given the high risk of rapid-onset HTLV-1-associated myelopathy, universal screening of solid organ donors is warranted. To minimize organ wastage, however, the specificity of HTLV screening tests must be improved. HTLV screening of organ donors in Europe has become mandatory in Spain and the United Kingdom. The advent of HTLV point-of-care kits would facilitate testing. Finally, increasing awareness of HTLV-1 will help those living with HTLV-1 to be tested, clinically monitored, and informed about transmission-preventive measures.http://www.sciencedirect.com/science/article/pii/S120197122400016XHTLV-1Screening policiesOnce-in-life testingTargeted screeningPregnant womenSexually transmitted infections |
| spellingShingle | Vicente Soriano Carmen de Mendoza Screening for HTLV-1 infection should be expanded in Europe International Journal of Infectious Diseases HTLV-1 Screening policies Once-in-life testing Targeted screening Pregnant women Sexually transmitted infections |
| title | Screening for HTLV-1 infection should be expanded in Europe |
| title_full | Screening for HTLV-1 infection should be expanded in Europe |
| title_fullStr | Screening for HTLV-1 infection should be expanded in Europe |
| title_full_unstemmed | Screening for HTLV-1 infection should be expanded in Europe |
| title_short | Screening for HTLV-1 infection should be expanded in Europe |
| title_sort | screening for htlv 1 infection should be expanded in europe |
| topic | HTLV-1 Screening policies Once-in-life testing Targeted screening Pregnant women Sexually transmitted infections |
| url | http://www.sciencedirect.com/science/article/pii/S120197122400016X |
| work_keys_str_mv | AT vicentesoriano screeningforhtlv1infectionshouldbeexpandedineurope AT carmendemendoza screeningforhtlv1infectionshouldbeexpandedineurope |