Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance
Thin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces the biocomp...
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4120 |
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| author | Lei Xing Hongyang Song Jinjian Wei Xue Wang Yaozhen Yang Pengbo Zhe Mingming Luan Jing Xu |
| author_facet | Lei Xing Hongyang Song Jinjian Wei Xue Wang Yaozhen Yang Pengbo Zhe Mingming Luan Jing Xu |
| author_sort | Lei Xing |
| collection | DOAJ |
| description | Thin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces the biocompatibility between the implant and the bone tissue, resulting in reduced osseointegration. In the present study, Ti specimens were surface-negatively ionized using a hot alkali activation method, after which polylysine and polydopamine layers were deposited on them using a layer-by-layer self-assembly method, then a quaternary ammonium salt (QAS) (EPTAC, DEQAS, MPA-N<sup>+</sup>) was grafted onto the surface of the coating. In all, 17 such composite coatings were prepared. Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the bacteriostatic rates of the coated specimens were 97.6 ± 2.0% and 98.4 ± 1.0%, respectively. Thus, this composite coating has the potential to increase the osseointegration and antibacterial performance of implantable Ti devices. |
| first_indexed | 2024-03-11T03:27:36Z |
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| id | doaj.art-a6719d7d7a3742a79ba5554fe8d92524 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:36Z |
| publishDate | 2023-05-01 |
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| series | Molecules |
| spelling | doaj.art-a6719d7d7a3742a79ba5554fe8d925242023-11-18T02:39:35ZengMDPI AGMolecules1420-30492023-05-012810412010.3390/molecules28104120Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial PerformanceLei Xing0Hongyang Song1Jinjian Wei2Xue Wang3Yaozhen Yang4Pengbo Zhe5Mingming Luan6Jing Xu7Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250100, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaThin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces the biocompatibility between the implant and the bone tissue, resulting in reduced osseointegration. In the present study, Ti specimens were surface-negatively ionized using a hot alkali activation method, after which polylysine and polydopamine layers were deposited on them using a layer-by-layer self-assembly method, then a quaternary ammonium salt (QAS) (EPTAC, DEQAS, MPA-N<sup>+</sup>) was grafted onto the surface of the coating. In all, 17 such composite coatings were prepared. Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the bacteriostatic rates of the coated specimens were 97.6 ± 2.0% and 98.4 ± 1.0%, respectively. Thus, this composite coating has the potential to increase the osseointegration and antibacterial performance of implantable Ti devices.https://www.mdpi.com/1420-3049/28/10/4120Tipolylysineself-assembly technologyEPTACDEQASMPA-N<sup>+</sup> |
| spellingShingle | Lei Xing Hongyang Song Jinjian Wei Xue Wang Yaozhen Yang Pengbo Zhe Mingming Luan Jing Xu Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance Molecules Ti polylysine self-assembly technology EPTAC DEQAS MPA-N<sup>+</sup> |
| title | Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance |
| title_full | Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance |
| title_fullStr | Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance |
| title_full_unstemmed | Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance |
| title_short | Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance |
| title_sort | influence of a composite polylysine polydopamine quaternary ammonium salt coating on titanium on its ostogenic and antibacterial performance |
| topic | Ti polylysine self-assembly technology EPTAC DEQAS MPA-N<sup>+</sup> |
| url | https://www.mdpi.com/1420-3049/28/10/4120 |
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