Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detectio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/4/1121 |
| _version_ | 1797603894119890944 |
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| author | Atiqah Zaid Norfarizah Hanim Hassan Philip J. Marriott Yong Foo Wong |
| author_facet | Atiqah Zaid Norfarizah Hanim Hassan Philip J. Marriott Yong Foo Wong |
| author_sort | Atiqah Zaid |
| collection | DOAJ |
| description | Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which ideally improve the screening and identification of disease biomarkers, as well as monitoring of therapeutic responses to treatment in complex biological matrixes. Selected recent GC×GC applications that focus on such biomarkers and metabolite profiling of the effects of drug administration are covered. In particular, the technical overview of recent GC×GC implementation with hyphenation to the key mass spectrometry (MS) technologies that provide the benefit of enhanced separation dimension analysis with MS domain differentiation is discussed. We conclude by highlighting the challenges in GC×GC for drug discovery and development with perspectives on future trends. |
| first_indexed | 2024-03-11T04:38:31Z |
| format | Article |
| id | doaj.art-a67236bcba9c4b2ead55c447626853d6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:38:31Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a67236bcba9c4b2ead55c447626853d62023-11-17T20:53:00ZengMDPI AGPharmaceutics1999-49232023-03-01154112110.3390/pharmaceutics15041121Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and AnalysisAtiqah Zaid0Norfarizah Hanim Hassan1Philip J. Marriott2Yong Foo Wong3Centre for Research on Multidimensional Separation Science, School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaCentre for Research on Multidimensional Separation Science, School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaAustralian Centre for Research on Separation Science, School of Chemistry, Monash University, Wellington Road, Clayton, Melbourne, VIC 3800, AustraliaCentre for Research on Multidimensional Separation Science, School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaOver the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which ideally improve the screening and identification of disease biomarkers, as well as monitoring of therapeutic responses to treatment in complex biological matrixes. Selected recent GC×GC applications that focus on such biomarkers and metabolite profiling of the effects of drug administration are covered. In particular, the technical overview of recent GC×GC implementation with hyphenation to the key mass spectrometry (MS) technologies that provide the benefit of enhanced separation dimension analysis with MS domain differentiation is discussed. We conclude by highlighting the challenges in GC×GC for drug discovery and development with perspectives on future trends.https://www.mdpi.com/1999-4923/15/4/1121GC×GCmetabolomicsdrug discovery and developmentmass spectrometrybiomarkerstuberculosis |
| spellingShingle | Atiqah Zaid Norfarizah Hanim Hassan Philip J. Marriott Yong Foo Wong Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis Pharmaceutics GC×GC metabolomics drug discovery and development mass spectrometry biomarkers tuberculosis |
| title | Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis |
| title_full | Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis |
| title_fullStr | Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis |
| title_full_unstemmed | Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis |
| title_short | Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis |
| title_sort | comprehensive two dimensional gas chromatography as a bioanalytical platform for drug discovery and analysis |
| topic | GC×GC metabolomics drug discovery and development mass spectrometry biomarkers tuberculosis |
| url | https://www.mdpi.com/1999-4923/15/4/1121 |
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