Hepatitis G virus infection among Iraqi patients with Chronic liver diseases.
Background: The hepatitis G virus( HGV), also called hepatitis GB virus, as a member of the Flaviviridae family distantly related to hepatitis C virus (HCV), Little is known about the frequency of HGV infection, the nature of the illness, or how to prevent it. What is known is that transfused blood ...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2010-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/979 |
| _version_ | 1827392700821798912 |
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| author | Eman Sh. Al-Obeidy Shatha F. Abdullah Faiza A. Mukhlis |
| author_facet | Eman Sh. Al-Obeidy Shatha F. Abdullah Faiza A. Mukhlis |
| author_sort | Eman Sh. Al-Obeidy |
| collection | DOAJ |
| description | Background: The hepatitis G virus( HGV), also called hepatitis GB virus, as a member of the Flaviviridae family distantly related to hepatitis C virus (HCV), Little is known about the frequency of HGV infection, the nature of the illness, or how to prevent it. What is known is that transfused blood containing HGV has caused some cases of hepatitis. They infect humans, but are not known to cause human disease. This virus can be transmitted efficiently by blood transfusion and by other parenteral mechanisms. Transient and long lasting infections with HGV have been documented in man.
Patients and methods: HBs Ag, Anti-HCV IgG and Anti-HGV IgG were detected by Enzyme-Linked Immunosorbent Assay (ELISA).HCV RNA on the other hand, has been detected using PCR technique in the serum of 75 Iraqi patients with chronic liver diseases in comparison to 15 healthy individuals.
Results: HGV infection was detected in 25% of blood donors, 30% of chronic hepatitis C, 25% of chronic hepatitis B, and 20% of cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found.
Conclusions: The percentage of HGV infection in chronic liver disease seems to be relatively high in our area 19 out of 90cases (21.11%). Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection, or in those with cryptogenic chronic liver disease. |
| first_indexed | 2024-03-08T17:37:12Z |
| format | Article |
| id | doaj.art-a672b9ee66be47c39659cb70ad2599e7 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:37:12Z |
| publishDate | 2010-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-a672b9ee66be47c39659cb70ad2599e72024-01-02T11:40:08ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572010-10-0152310.32007/jfacmedbagdad.v3301-305%Hepatitis G virus infection among Iraqi patients with Chronic liver diseases.Eman Sh. Al-Obeidy0Shatha F. Abdullah1Faiza A. Mukhlis2Teaching Laboratories in Baghdad Medical city.Dept. of Microbiology. College of Medicine .University of Baghdad.Dept. of Microbiology. College of Medicine .University of Baghdad.Background: The hepatitis G virus( HGV), also called hepatitis GB virus, as a member of the Flaviviridae family distantly related to hepatitis C virus (HCV), Little is known about the frequency of HGV infection, the nature of the illness, or how to prevent it. What is known is that transfused blood containing HGV has caused some cases of hepatitis. They infect humans, but are not known to cause human disease. This virus can be transmitted efficiently by blood transfusion and by other parenteral mechanisms. Transient and long lasting infections with HGV have been documented in man. Patients and methods: HBs Ag, Anti-HCV IgG and Anti-HGV IgG were detected by Enzyme-Linked Immunosorbent Assay (ELISA).HCV RNA on the other hand, has been detected using PCR technique in the serum of 75 Iraqi patients with chronic liver diseases in comparison to 15 healthy individuals. Results: HGV infection was detected in 25% of blood donors, 30% of chronic hepatitis C, 25% of chronic hepatitis B, and 20% of cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions: The percentage of HGV infection in chronic liver disease seems to be relatively high in our area 19 out of 90cases (21.11%). Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection, or in those with cryptogenic chronic liver disease.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/979HGV, chronic liver disease, blood donors. |
| spellingShingle | Eman Sh. Al-Obeidy Shatha F. Abdullah Faiza A. Mukhlis Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. مجلة كلية الطب HGV, chronic liver disease, blood donors. |
| title | Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. |
| title_full | Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. |
| title_fullStr | Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. |
| title_full_unstemmed | Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. |
| title_short | Hepatitis G virus infection among Iraqi patients with Chronic liver diseases. |
| title_sort | hepatitis g virus infection among iraqi patients with chronic liver diseases |
| topic | HGV, chronic liver disease, blood donors. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/979 |
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