Genes associated with Alzheimer's disease: an overview and current status
Mohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most c...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-05-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/genes-associated-with-alzheimer39s-disease-an-overview-and-current-sta-peer-reviewed-article-CIA |
| _version_ | 1819013138194890752 |
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| author | Giri M Zhang M Lü Y |
| author_facet | Giri M Zhang M Lü Y |
| author_sort | Giri M |
| collection | DOAJ |
| description | Mohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. Keywords: Alzheimer’s disease, amyloid precursor protein, genome-wide association studies, biological pathways, presenilin 1, presenilin 2, neuropathology |
| first_indexed | 2024-12-21T01:55:11Z |
| format | Article |
| id | doaj.art-a6733414e6914da89f2895a440fe667f |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-21T01:55:11Z |
| publishDate | 2016-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-a6733414e6914da89f2895a440fe667f2022-12-21T19:19:48ZengDove Medical PressClinical Interventions in Aging1178-19982016-05-01Volume 1166568126973Genes associated with Alzheimer's disease: an overview and current statusGiri MZhang MLü YMohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. Keywords: Alzheimer’s disease, amyloid precursor protein, genome-wide association studies, biological pathways, presenilin 1, presenilin 2, neuropathologyhttps://www.dovepress.com/genes-associated-with-alzheimer39s-disease-an-overview-and-current-sta-peer-reviewed-article-CIAAlzheimer diseaseAmyloid precursor proteinGenome wide association studiesBiological pathwaysPresenilin 1Presenilin 2Neuropathology |
| spellingShingle | Giri M Zhang M Lü Y Genes associated with Alzheimer's disease: an overview and current status Clinical Interventions in Aging Alzheimer disease Amyloid precursor protein Genome wide association studies Biological pathways Presenilin 1 Presenilin 2 Neuropathology |
| title | Genes associated with Alzheimer's disease: an overview and current status |
| title_full | Genes associated with Alzheimer's disease: an overview and current status |
| title_fullStr | Genes associated with Alzheimer's disease: an overview and current status |
| title_full_unstemmed | Genes associated with Alzheimer's disease: an overview and current status |
| title_short | Genes associated with Alzheimer's disease: an overview and current status |
| title_sort | genes associated with alzheimer 39 s disease an overview and current status |
| topic | Alzheimer disease Amyloid precursor protein Genome wide association studies Biological pathways Presenilin 1 Presenilin 2 Neuropathology |
| url | https://www.dovepress.com/genes-associated-with-alzheimer39s-disease-an-overview-and-current-sta-peer-reviewed-article-CIA |
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