Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults
Psychotic disorders often develop as the continuum of subclinical symptoms that include hallucination-like and delusion-like experiences, and are commonly referred to as psychotic-like experiences (PLEs). To date, a number of neurodevelopmental risk factors of psychosis have been detected, yet their...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Comprehensive Psychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X23000226 |
| _version_ | 1797842862817148928 |
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| author | Błażej Misiak Dorota Frydecka Krzysztof Kowalski Jerzy Samochowiec Marcin Jabłoński Łukasz Gawęda |
| author_facet | Błażej Misiak Dorota Frydecka Krzysztof Kowalski Jerzy Samochowiec Marcin Jabłoński Łukasz Gawęda |
| author_sort | Błażej Misiak |
| collection | DOAJ |
| description | Psychotic disorders often develop as the continuum of subclinical symptoms that include hallucination-like and delusion-like experiences, and are commonly referred to as psychotic-like experiences (PLEs). To date, a number of neurodevelopmental risk factors of psychosis have been detected, yet their mutual interplay remains unknown. Therefore, we aimed to investigate the additive association of childhood trauma history, reading disabilities and symptoms of attention-deficit/hyperactivity disorder (ADHD) with psychosis proneness. A total of 3000 young adults (58.3% females, aged 18–35 years) with a negative history of psychiatric treatment were recruited to the cross-sectional study through computer-assisted web interview. Self-reports were administered to measure childhood trauma history, ADHD symptoms and reading disabilities. Linear regression analyses revealed significant main associations of childhood trauma history and reading disabilities with higher levels of PLEs. There were no significant main associations of ADHD with the level of PLEs. However, the associations of all possible interactions between neurodevelopmental risk factors with the level of PLEs were significant. Our findings suggest that childhood trauma history and reading disabilities may additively increase a risk of psychosis. The present findings bring new implications for early intervention strategies in psychosis and posit the rationale of recording the accumulation of neurodevelopmental vulnerabilities in clinical practice. |
| first_indexed | 2024-04-09T16:55:02Z |
| format | Article |
| id | doaj.art-a673f64683b44b6c976831bef08859d0 |
| institution | Directory Open Access Journal |
| issn | 0010-440X |
| language | English |
| last_indexed | 2024-04-09T16:55:02Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj.art-a673f64683b44b6c976831bef08859d02023-04-21T06:40:36ZengElsevierComprehensive Psychiatry0010-440X2023-05-01123152385Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adultsBłażej Misiak0Dorota Frydecka1Krzysztof Kowalski2Jerzy Samochowiec3Marcin Jabłoński4Łukasz Gawęda5Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Corresponding author at: Department of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.Department of Psychiatry, Wroclaw Medical University, Wroclaw, PolandDepartment of Psychiatry, Wroclaw Medical University, Wroclaw, PolandDepartment of Psychiatry, Pomeranian Medical University, Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University, Szczecin, PolandExperimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, PolandPsychotic disorders often develop as the continuum of subclinical symptoms that include hallucination-like and delusion-like experiences, and are commonly referred to as psychotic-like experiences (PLEs). To date, a number of neurodevelopmental risk factors of psychosis have been detected, yet their mutual interplay remains unknown. Therefore, we aimed to investigate the additive association of childhood trauma history, reading disabilities and symptoms of attention-deficit/hyperactivity disorder (ADHD) with psychosis proneness. A total of 3000 young adults (58.3% females, aged 18–35 years) with a negative history of psychiatric treatment were recruited to the cross-sectional study through computer-assisted web interview. Self-reports were administered to measure childhood trauma history, ADHD symptoms and reading disabilities. Linear regression analyses revealed significant main associations of childhood trauma history and reading disabilities with higher levels of PLEs. There were no significant main associations of ADHD with the level of PLEs. However, the associations of all possible interactions between neurodevelopmental risk factors with the level of PLEs were significant. Our findings suggest that childhood trauma history and reading disabilities may additively increase a risk of psychosis. The present findings bring new implications for early intervention strategies in psychosis and posit the rationale of recording the accumulation of neurodevelopmental vulnerabilities in clinical practice.http://www.sciencedirect.com/science/article/pii/S0010440X23000226PsychosisEarly-life stressChildhood maltreatmentADHDDyslexia |
| spellingShingle | Błażej Misiak Dorota Frydecka Krzysztof Kowalski Jerzy Samochowiec Marcin Jabłoński Łukasz Gawęda Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults Comprehensive Psychiatry Psychosis Early-life stress Childhood maltreatment ADHD Dyslexia |
| title | Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults |
| title_full | Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults |
| title_fullStr | Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults |
| title_full_unstemmed | Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults |
| title_short | Associations of neurodevelopmental risk factors with psychosis proneness: Findings from a non-clinical sample of young adults |
| title_sort | associations of neurodevelopmental risk factors with psychosis proneness findings from a non clinical sample of young adults |
| topic | Psychosis Early-life stress Childhood maltreatment ADHD Dyslexia |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X23000226 |
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