Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid
Impairment of the immune response in MRONJ (medication-related osteonecrosis of the jaws) is one of the still unclear etiopathogenic mechanisms of this condition encountered in cancer patients treated with bisphosphonates, with negative effects on the patient’s quality of life. The aim of the presen...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14345 |
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| author | George Adrian Ciobanu Laurențiu Mogoantă Sanda Mihaela Popescu Mihaela Ionescu Cristina Maria Munteanu Ionela Elisabeta Staicu Răzvan Mercuț Cristian Corneliu Georgescu Monica Scrieciu Daniel Vlad Adrian Camen |
| author_facet | George Adrian Ciobanu Laurențiu Mogoantă Sanda Mihaela Popescu Mihaela Ionescu Cristina Maria Munteanu Ionela Elisabeta Staicu Răzvan Mercuț Cristian Corneliu Georgescu Monica Scrieciu Daniel Vlad Adrian Camen |
| author_sort | George Adrian Ciobanu |
| collection | DOAJ |
| description | Impairment of the immune response in MRONJ (medication-related osteonecrosis of the jaws) is one of the still unclear etiopathogenic mechanisms of this condition encountered in cancer patients treated with bisphosphonates, with negative effects on the patient’s quality of life. The aim of the present study was to correlate the immune response with etiopathogenic factors via immunohistochemical evaluation of the maxillary tissues in zoledronic acid osteonecrosis. The retrospective study included a group of 51 patients with various types of cancers, diagnosed with stage 2 or 3 MRONJ at zoledronic acid and treated surgically. Immunohistochemical expressions of αSMA, CD3, CD4, CD8, CD20, CD79α, CD68, CD204, and tryptase were evaluated. Immunohistochemical markers expressions were statistically analyzed according to the duration of the treatment, the trigger factor, the location of the MRONJ, and the healing status. Analysis of the immune response included T lymphocytes, B lymphocytes, plasma cells, macrophages, and mast cells. The duration of treatment significantly influenced the immunohistochemical expression of most markers (<i>p</i> < 0.05). For an increasing trend in treatment duration, a decreasing trend in marker score was observed, suggesting an inverse correlation. The expression of the markers was different depending on the trigger factor, on MRONJ localization (maxilla/mandible), and the healing status, being more intense in patients cured per primam compared to those who had relapses. The patient’s immune response was negatively influenced by the duration of the treatment, the trigger factor, the location of the lesion in the mandible, and the recurrence of MRONJ. |
| first_indexed | 2024-03-10T22:39:25Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a674e3fa3865472a8fc9aab8526551b02023-11-19T11:11:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181434510.3390/ijms241814345Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic AcidGeorge Adrian Ciobanu0Laurențiu Mogoantă1Sanda Mihaela Popescu2Mihaela Ionescu3Cristina Maria Munteanu4Ionela Elisabeta Staicu5Răzvan Mercuț6Cristian Corneliu Georgescu7Monica Scrieciu8Daniel Vlad9Adrian Camen10Department of Oral Rehabilitation, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Oral Rehabilitation, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Orthodontics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Plastic Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Pharmacology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Prosthetic Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Oral and Maxillofacial Surgery, Dental Medicine Faculty, Ovidius University of Constanța, 900470 Constanța, RomaniaDepartment of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaImpairment of the immune response in MRONJ (medication-related osteonecrosis of the jaws) is one of the still unclear etiopathogenic mechanisms of this condition encountered in cancer patients treated with bisphosphonates, with negative effects on the patient’s quality of life. The aim of the present study was to correlate the immune response with etiopathogenic factors via immunohistochemical evaluation of the maxillary tissues in zoledronic acid osteonecrosis. The retrospective study included a group of 51 patients with various types of cancers, diagnosed with stage 2 or 3 MRONJ at zoledronic acid and treated surgically. Immunohistochemical expressions of αSMA, CD3, CD4, CD8, CD20, CD79α, CD68, CD204, and tryptase were evaluated. Immunohistochemical markers expressions were statistically analyzed according to the duration of the treatment, the trigger factor, the location of the MRONJ, and the healing status. Analysis of the immune response included T lymphocytes, B lymphocytes, plasma cells, macrophages, and mast cells. The duration of treatment significantly influenced the immunohistochemical expression of most markers (<i>p</i> < 0.05). For an increasing trend in treatment duration, a decreasing trend in marker score was observed, suggesting an inverse correlation. The expression of the markers was different depending on the trigger factor, on MRONJ localization (maxilla/mandible), and the healing status, being more intense in patients cured per primam compared to those who had relapses. The patient’s immune response was negatively influenced by the duration of the treatment, the trigger factor, the location of the lesion in the mandible, and the recurrence of MRONJ.https://www.mdpi.com/1422-0067/24/18/14345MRONJzoledronic acidimmunohistochemical markers |
| spellingShingle | George Adrian Ciobanu Laurențiu Mogoantă Sanda Mihaela Popescu Mihaela Ionescu Cristina Maria Munteanu Ionela Elisabeta Staicu Răzvan Mercuț Cristian Corneliu Georgescu Monica Scrieciu Daniel Vlad Adrian Camen Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid International Journal of Molecular Sciences MRONJ zoledronic acid immunohistochemical markers |
| title | Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid |
| title_full | Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid |
| title_fullStr | Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid |
| title_full_unstemmed | Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid |
| title_short | Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid |
| title_sort | correlations between immune response and etiopathogenic factors of medication related osteonecrosis of the jaw in cancer patients treated with zoledronic acid |
| topic | MRONJ zoledronic acid immunohistochemical markers |
| url | https://www.mdpi.com/1422-0067/24/18/14345 |
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