Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinct cellular actions suggesting divergence in downstream intrac...

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Bibliographic Details
Main Authors: Meng Zhao, Niels Banhos Danneskiold-Samsøe, Livia Ulicna, Quennie Nguyen, Laetitia Voilquin, David E Lee, James P White, Zewen Jiang, Nickeisha Cuthbert, Shrika Paramasivam, Ewa Bielczyk-Maczynska, Capucine Van Rechem, Katrin J Svensson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
proteomics
signaling
muscle
Online Access:https://elifesciences.org/articles/80014

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