Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis
Most tumours exhibit significant heterogeneity and are best described as communities of cellular populations competing for resources. Growing experimental evidence also suggests that cooperation between cancer clones is important as well for the maintenance of tumour heterogeneity and tumour progres...
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-02-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201532 |
| _version_ | 1818700732888514560 |
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| author | Alessandro Esposito |
| author_facet | Alessandro Esposito |
| author_sort | Alessandro Esposito |
| collection | DOAJ |
| description | Most tumours exhibit significant heterogeneity and are best described as communities of cellular populations competing for resources. Growing experimental evidence also suggests that cooperation between cancer clones is important as well for the maintenance of tumour heterogeneity and tumour progression. However, a role for cell communication during the earliest steps in oncogenesis is not well characterized despite its vital importance in normal tissue and clinically manifest tumours. Here, we present a simple analytical model and stochastic lattice-based simulations to study how the interaction between the mutational process and cell-to-cell communication in three-dimensional tissue architecture might contribute to shape early oncogenesis. We show that non-cell-autonomous mechanisms of carcinogenesis could support and accelerate pre-cancerous clonal expansion through the cooperation of different, non- or partially transformed mutants. We predict the existence of a ‘cell-autonomous time horizon', a time before which cooperation between cell-to-cell communication and DNA mutations might be one of the most fundamental forces shaping the early stages of oncogenesis. The understanding of this process could shed new light on the mechanisms leading to clinically manifest cancers. |
| first_indexed | 2024-12-17T15:09:38Z |
| format | Article |
| id | doaj.art-a67a673d2d19440ca48b0bec7f267bd7 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-17T15:09:38Z |
| publishDate | 2021-02-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-a67a673d2d19440ca48b0bec7f267bd72022-12-21T21:43:43ZengThe Royal SocietyRoyal Society Open Science2054-57032021-02-018210.1098/rsos.201532201532Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesisAlessandro EspositoMost tumours exhibit significant heterogeneity and are best described as communities of cellular populations competing for resources. Growing experimental evidence also suggests that cooperation between cancer clones is important as well for the maintenance of tumour heterogeneity and tumour progression. However, a role for cell communication during the earliest steps in oncogenesis is not well characterized despite its vital importance in normal tissue and clinically manifest tumours. Here, we present a simple analytical model and stochastic lattice-based simulations to study how the interaction between the mutational process and cell-to-cell communication in three-dimensional tissue architecture might contribute to shape early oncogenesis. We show that non-cell-autonomous mechanisms of carcinogenesis could support and accelerate pre-cancerous clonal expansion through the cooperation of different, non- or partially transformed mutants. We predict the existence of a ‘cell-autonomous time horizon', a time before which cooperation between cell-to-cell communication and DNA mutations might be one of the most fundamental forces shaping the early stages of oncogenesis. The understanding of this process could shed new light on the mechanisms leading to clinically manifest cancers.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201532oncogenesisnon-cell-autonomousmodel |
| spellingShingle | Alessandro Esposito Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis Royal Society Open Science oncogenesis non-cell-autonomous model |
| title | Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis |
| title_full | Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis |
| title_fullStr | Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis |
| title_full_unstemmed | Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis |
| title_short | Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis |
| title_sort | cooperation of partially transformed clones an invisible force behind the early stages of carcinogenesis |
| topic | oncogenesis non-cell-autonomous model |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201532 |
| work_keys_str_mv | AT alessandroesposito cooperationofpartiallytransformedclonesaninvisibleforcebehindtheearlystagesofcarcinogenesis |