Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats

Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats

Andrographolide (ADG) is contained in bitter plants, and its effects are widely thought to be associated with taste receptors. The current study used animal studies and cell lines to investigate the role of ADG in diabetic models. The Takeda G-protein-coupled receptor (TGR5) was directly influenced...

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Bibliographic Details
Main Authors: Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Cheng
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
andrographolide
DPP-4
GLP-1
insulin
Takeda G-protein-coupled receptor
diabetic rats
Online Access:https://www.mdpi.com/1424-8247/16/10/1417

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