Symposium 6: HLA and Non-HLA genetic predisposition
Symposium 6: Autoimmune diabetes: heterogeneity in its clinical presentations HLA and Non-HLA genetic predisposition Type 1 diabetes is a multifactorial autoimmune disease. Genetic and environmental factors, and their interaction, influence multiple mechanisms that contribute to varying degrees of...
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| Format: | Article |
| Language: | Spanish |
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Sello Editorial Lugones
2020-11-01
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| Series: | Revista de la Sociedad Argentina de Diabetes |
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| Online Access: | https://revistasad.com/index.php/diabetes/article/view/297 |
| Summary: | Symposium 6: Autoimmune diabetes: heterogeneity in its clinical presentations
HLA and Non-HLA genetic predisposition
Type 1 diabetes is a multifactorial autoimmune disease. Genetic and environmental factors, and their interaction, influence multiple mechanisms that contribute to varying degrees of diabetes development and progression in every patient.
Heterogeneity is due to its polygenic nature, that is, multiple genes interactions and the contribution of environmental factors that trigger the pathology. The most frequent genetic variations reflect heterogeneity in each manifestation: early or juvenile, adults aged between 20 and 40 years old or in patients with LADA (Latent Autoimmune Diabetes in Adults). |
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| ISSN: | 0325-5247 2346-9420 |