Iron induces two distinct Ca2+ signalling cascades in astrocytes
Wenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as a barrier to excessive iron in the brain, thereby...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02060-x |
| _version_ | 1818433789845569536 |
|---|---|
| author | Wenzheng Guan Maosheng Xia Ming Ji Beina Chen Shuai Li Manman Zhang Shanshan Liang Binjie Chen Wenliang Gong Chengyi Dong Gehua Wen Xiaoni Zhan Dianjun Zhang Xinyu Li Yuefei Zhou Dawei Guan Alexei Verkhratsky Baoman Li |
| author_facet | Wenzheng Guan Maosheng Xia Ming Ji Beina Chen Shuai Li Manman Zhang Shanshan Liang Binjie Chen Wenliang Gong Chengyi Dong Gehua Wen Xiaoni Zhan Dianjun Zhang Xinyu Li Yuefei Zhou Dawei Guan Alexei Verkhratsky Baoman Li |
| author_sort | Wenzheng Guan |
| collection | DOAJ |
| description | Wenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as a barrier to excessive iron in the brain, thereby improving our understanding of the role of astrocytes in normal neurodevelopment. |
| first_indexed | 2024-12-14T16:26:41Z |
| format | Article |
| id | doaj.art-a67c1f1c03484bec8f4a7b5d8d413b09 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T16:26:41Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a67c1f1c03484bec8f4a7b5d8d413b092022-12-21T22:54:41ZengNature PortfolioCommunications Biology2399-36422021-05-014111310.1038/s42003-021-02060-xIron induces two distinct Ca2+ signalling cascades in astrocytesWenzheng Guan0Maosheng Xia1Ming Ji2Beina Chen3Shuai Li4Manman Zhang5Shanshan Liang6Binjie Chen7Wenliang Gong8Chengyi Dong9Gehua Wen10Xiaoni Zhan11Dianjun Zhang12Xinyu Li13Yuefei Zhou14Dawei Guan15Alexei Verkhratsky16Baoman Li17Practical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityDepartment of Orthopaedics, The First Hospital, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityDepartment of Orthopaedics, The First Hospital, China Medical UniversityDepartment of Forensic Pathology, School of Forensic Medicine, China Medical UniversityDepartment of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical UniversityPractical Teaching Centre, School of Forensic Medicine, China Medical UniversityWenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as a barrier to excessive iron in the brain, thereby improving our understanding of the role of astrocytes in normal neurodevelopment.https://doi.org/10.1038/s42003-021-02060-x |
| spellingShingle | Wenzheng Guan Maosheng Xia Ming Ji Beina Chen Shuai Li Manman Zhang Shanshan Liang Binjie Chen Wenliang Gong Chengyi Dong Gehua Wen Xiaoni Zhan Dianjun Zhang Xinyu Li Yuefei Zhou Dawei Guan Alexei Verkhratsky Baoman Li Iron induces two distinct Ca2+ signalling cascades in astrocytes Communications Biology |
| title | Iron induces two distinct Ca2+ signalling cascades in astrocytes |
| title_full | Iron induces two distinct Ca2+ signalling cascades in astrocytes |
| title_fullStr | Iron induces two distinct Ca2+ signalling cascades in astrocytes |
| title_full_unstemmed | Iron induces two distinct Ca2+ signalling cascades in astrocytes |
| title_short | Iron induces two distinct Ca2+ signalling cascades in astrocytes |
| title_sort | iron induces two distinct ca2 signalling cascades in astrocytes |
| url | https://doi.org/10.1038/s42003-021-02060-x |
| work_keys_str_mv | AT wenzhengguan ironinducestwodistinctca2signallingcascadesinastrocytes AT maoshengxia ironinducestwodistinctca2signallingcascadesinastrocytes AT mingji ironinducestwodistinctca2signallingcascadesinastrocytes AT beinachen ironinducestwodistinctca2signallingcascadesinastrocytes AT shuaili ironinducestwodistinctca2signallingcascadesinastrocytes AT manmanzhang ironinducestwodistinctca2signallingcascadesinastrocytes AT shanshanliang ironinducestwodistinctca2signallingcascadesinastrocytes AT binjiechen ironinducestwodistinctca2signallingcascadesinastrocytes AT wenlianggong ironinducestwodistinctca2signallingcascadesinastrocytes AT chengyidong ironinducestwodistinctca2signallingcascadesinastrocytes AT gehuawen ironinducestwodistinctca2signallingcascadesinastrocytes AT xiaonizhan ironinducestwodistinctca2signallingcascadesinastrocytes AT dianjunzhang ironinducestwodistinctca2signallingcascadesinastrocytes AT xinyuli ironinducestwodistinctca2signallingcascadesinastrocytes AT yuefeizhou ironinducestwodistinctca2signallingcascadesinastrocytes AT daweiguan ironinducestwodistinctca2signallingcascadesinastrocytes AT alexeiverkhratsky ironinducestwodistinctca2signallingcascadesinastrocytes AT baomanli ironinducestwodistinctca2signallingcascadesinastrocytes |