Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11 [version 1; peer review: 1 approved, 2 approved with reservations]

Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11 [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs. Drugs such as rifampicin and glibenclamide inhibit BSEP. Progressive familial intrahepatic cholestasis type-2, a lethal pediatric disease, some forms of intrahepa...

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Bibliographic Details
Main Authors: Nisha Vats, Ravi Chandra Dubey, Madhusudana Girija Sanal, Pankaj Taneja, Senthil Kumar Venugopal
Format: Article
Language:English
Published: F1000 Research Ltd 2020-12-01
Series:F1000Research
Online Access:https://f1000research.com/articles/9-1497/v1

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