Prototyping a precision oncology 3.0 rapid learning platform

Abstract Background We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype plat...

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Main Authors: Connor Sweetnam, Simone Mocellin, Michael Krauthammer, Nathaniel Knopf, Robert Baertsch, Jeff Shrager
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Bioinformatics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12859-018-2374-0
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author Connor Sweetnam
Simone Mocellin
Michael Krauthammer
Nathaniel Knopf
Robert Baertsch
Jeff Shrager
author_facet Connor Sweetnam
Simone Mocellin
Michael Krauthammer
Nathaniel Knopf
Robert Baertsch
Jeff Shrager
author_sort Connor Sweetnam
collection DOAJ
description Abstract Background We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype platform. Conclusions The design choices made in this implementation rest upon ten constitutive hypotheses, which, taken together, define a particular view of how a rapid learning medical platform might be defined, organized, and implemented.
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spelling doaj.art-a67d90bfb6cc4e8cb9fcb013b7ddc5932022-12-21T18:53:58ZengBMCBMC Bioinformatics1471-21052018-09-0119111910.1186/s12859-018-2374-0Prototyping a precision oncology 3.0 rapid learning platformConnor Sweetnam0Simone Mocellin1Michael Krauthammer2Nathaniel Knopf3Robert Baertsch4Jeff Shrager5Cancer CommonsIstituto Oncologico Veneto, IOV-IRCSS; and Department of Surgery Oncology and Gastroenterology, University of PadovaProgram for Computational Biology and Bioinformatics, Yale UniversityCancer CommonsCancer CommonsCancer CommonsAbstract Background We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype platform. Conclusions The design choices made in this implementation rest upon ten constitutive hypotheses, which, taken together, define a particular view of how a rapid learning medical platform might be defined, organized, and implemented.http://link.springer.com/article/10.1186/s12859-018-2374-0Natural language processingPrecision oncologyControlled natural languageNanopublicationTreatment reasoningRapid learning
spellingShingle Connor Sweetnam
Simone Mocellin
Michael Krauthammer
Nathaniel Knopf
Robert Baertsch
Jeff Shrager
Prototyping a precision oncology 3.0 rapid learning platform
BMC Bioinformatics
Natural language processing
Precision oncology
Controlled natural language
Nanopublication
Treatment reasoning
Rapid learning
title Prototyping a precision oncology 3.0 rapid learning platform
title_full Prototyping a precision oncology 3.0 rapid learning platform
title_fullStr Prototyping a precision oncology 3.0 rapid learning platform
title_full_unstemmed Prototyping a precision oncology 3.0 rapid learning platform
title_short Prototyping a precision oncology 3.0 rapid learning platform
title_sort prototyping a precision oncology 3 0 rapid learning platform
topic Natural language processing
Precision oncology
Controlled natural language
Nanopublication
Treatment reasoning
Rapid learning
url http://link.springer.com/article/10.1186/s12859-018-2374-0
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AT simonemocellin prototypingaprecisiononcology30rapidlearningplatform
AT michaelkrauthammer prototypingaprecisiononcology30rapidlearningplatform
AT nathanielknopf prototypingaprecisiononcology30rapidlearningplatform
AT robertbaertsch prototypingaprecisiononcology30rapidlearningplatform
AT jeffshrager prototypingaprecisiononcology30rapidlearningplatform