Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study
Objectives To determine the diagnostic yield of screening patients for SARS-CoV-2 who were admitted with a diagnosis unrelated to COVID-19 and to identify risk factors for positive tests.Design Cohort from the Canadian COVID-19 Emergency Department Rapid Response Network registry.Setting 30 acute ca...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/8/e057852.full |
| _version_ | 1811321938741559296 |
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| author | Eddy Lang Jeffrey P Hau Corinne M Hohl Raoul Daoust Ivy Cheng Andrew D McRae Philip Davis Rhonda Rosychuk Joel Turner Jaspreet Khangura Maja Stachura Patrick T Fok Baljeet Brar |
| author_facet | Eddy Lang Jeffrey P Hau Corinne M Hohl Raoul Daoust Ivy Cheng Andrew D McRae Philip Davis Rhonda Rosychuk Joel Turner Jaspreet Khangura Maja Stachura Patrick T Fok Baljeet Brar |
| author_sort | Eddy Lang |
| collection | DOAJ |
| description | Objectives To determine the diagnostic yield of screening patients for SARS-CoV-2 who were admitted with a diagnosis unrelated to COVID-19 and to identify risk factors for positive tests.Design Cohort from the Canadian COVID-19 Emergency Department Rapid Response Network registry.Setting 30 acute care hospitals across Canada.Participants Patients hospitalised for non-COVID-19-related diagnoses who were tested for SARS-CoV-2 between 1 March and 29 December 2020.Main outcome Positive nucleic acid amplification test for SARS-CoV-2.Outcome measure Diagnostic yield.Results We enrolled 15 690 consecutive eligible adults who were admitted to hospital without clinically suspected COVID-19. Among these patients, 122 tested positive for COVID-19, resulting in a diagnostic yield of 0.8% (95% CI 0.64% to 0.92%). Factors associated with a positive test included presence of fever, being a healthcare worker, having a positive household contact or institutional exposure, and living in an area with higher 7-day average incident COVID-19 cases.Conclusions Universal screening of hospitalised patients for COVID-19 across two pandemic waves had a low diagnostic yield and should be informed by individual-level risk assessment in addition to regional COVID-19 prevalence.Trial registration number NCT04702945. |
| first_indexed | 2024-04-13T13:26:23Z |
| format | Article |
| id | doaj.art-a67e234267ca466bba22e918470de628 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-13T13:26:23Z |
| publishDate | 2022-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-a67e234267ca466bba22e918470de6282022-12-22T02:45:08ZengBMJ Publishing GroupBMJ Open2044-60552022-08-0112810.1136/bmjopen-2021-057852Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort studyEddy Lang0Jeffrey P Hau1Corinne M Hohl2Raoul Daoust3Ivy Cheng4Andrew D McRae5Philip Davis6Rhonda Rosychuk7Joel Turner8Jaspreet Khangura9Maja Stachura10Patrick T Fok11Baljeet Brar121 University of Calgary, Calgary, Alberta, CanadaFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKDepartment of Emergency Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, CanadaDépartement Médecine de Famille et Médecine d’Urgence, Université de Montréal, Montreal, Quebec, CanadaDepartment of Emergency Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada11 Department of Emergency Medicine, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, CanadaDepartment of Emergency Medicine, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, CanadaDepartment of Paediatrics, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, CanadaDepartment of Emergency Medicine, McGill University, Montreal, Quebec, CanadaDepartment of Emergency Medicine, Northeast Community Health Centre, Edmonton, Alberta, CanadaDepartment of Emergency Medicine, The University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaDepartment of Emergency Medicine, The University of British Columbia, Vancouver, British Columbia, CanadaObjectives To determine the diagnostic yield of screening patients for SARS-CoV-2 who were admitted with a diagnosis unrelated to COVID-19 and to identify risk factors for positive tests.Design Cohort from the Canadian COVID-19 Emergency Department Rapid Response Network registry.Setting 30 acute care hospitals across Canada.Participants Patients hospitalised for non-COVID-19-related diagnoses who were tested for SARS-CoV-2 between 1 March and 29 December 2020.Main outcome Positive nucleic acid amplification test for SARS-CoV-2.Outcome measure Diagnostic yield.Results We enrolled 15 690 consecutive eligible adults who were admitted to hospital without clinically suspected COVID-19. Among these patients, 122 tested positive for COVID-19, resulting in a diagnostic yield of 0.8% (95% CI 0.64% to 0.92%). Factors associated with a positive test included presence of fever, being a healthcare worker, having a positive household contact or institutional exposure, and living in an area with higher 7-day average incident COVID-19 cases.Conclusions Universal screening of hospitalised patients for COVID-19 across two pandemic waves had a low diagnostic yield and should be informed by individual-level risk assessment in addition to regional COVID-19 prevalence.Trial registration number NCT04702945.https://bmjopen.bmj.com/content/12/8/e057852.full |
| spellingShingle | Eddy Lang Jeffrey P Hau Corinne M Hohl Raoul Daoust Ivy Cheng Andrew D McRae Philip Davis Rhonda Rosychuk Joel Turner Jaspreet Khangura Maja Stachura Patrick T Fok Baljeet Brar Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study BMJ Open |
| title | Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study |
| title_full | Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study |
| title_fullStr | Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study |
| title_full_unstemmed | Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study |
| title_short | Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study |
| title_sort | diagnostic yield of screening for sars cov 2 among patients admitted to hospital for alternate diagnoses an observational cohort study |
| url | https://bmjopen.bmj.com/content/12/8/e057852.full |
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