From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models
<i>Klebsiella pneumoniae</i> is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their acce...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/6/1282 |
| _version_ | 1827689939322535936 |
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| author | Laura Joseph Thomas Merciecca Christiane Forestier Damien Balestrino Sylvie Miquel |
| author_facet | Laura Joseph Thomas Merciecca Christiane Forestier Damien Balestrino Sylvie Miquel |
| author_sort | Laura Joseph |
| collection | DOAJ |
| description | <i>Klebsiella pneumoniae</i> is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their accessory genome, which determines bacterial pathogenicity and the host immune response. The aim of this survey is to present an overview of the murine models mimicking <i>K. pneumoniae</i> infectious processes (i.e., gastrointestinal colonization, urinary, pulmonary, and systemic infections), and the bacterial functions deployed to colonize and disseminate into the host. These in vivo approaches are pivotal to develop new therapeutics to limit <i>K. pneumoniae</i> infections via a modulation of the immune responses and/or microbiota. |
| first_indexed | 2024-03-10T10:28:31Z |
| format | Article |
| id | doaj.art-a67ec72900a3415f94f978f3e3cd0fe7 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T10:28:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a67ec72900a3415f94f978f3e3cd0fe72023-11-21T23:51:04ZengMDPI AGMicroorganisms2076-26072021-06-0196128210.3390/microorganisms9061282From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine ModelsLaura Joseph0Thomas Merciecca1Christiane Forestier2Damien Balestrino3Sylvie Miquel4Laboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, FranceLaboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, FranceLaboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, FranceLaboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, FranceLaboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, France<i>Klebsiella pneumoniae</i> is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their accessory genome, which determines bacterial pathogenicity and the host immune response. The aim of this survey is to present an overview of the murine models mimicking <i>K. pneumoniae</i> infectious processes (i.e., gastrointestinal colonization, urinary, pulmonary, and systemic infections), and the bacterial functions deployed to colonize and disseminate into the host. These in vivo approaches are pivotal to develop new therapeutics to limit <i>K. pneumoniae</i> infections via a modulation of the immune responses and/or microbiota.https://www.mdpi.com/2076-2607/9/6/1282<i>Klebsiella pneumoniae</i>in vivo murine modelscolonization and virulence factorsnew therapeutics |
| spellingShingle | Laura Joseph Thomas Merciecca Christiane Forestier Damien Balestrino Sylvie Miquel From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models Microorganisms <i>Klebsiella pneumoniae</i> in vivo murine models colonization and virulence factors new therapeutics |
| title | From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models |
| title_full | From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models |
| title_fullStr | From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models |
| title_full_unstemmed | From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models |
| title_short | From <i>Klebsiella pneumoniae</i> Colonization to Dissemination: An Overview of Studies Implementing Murine Models |
| title_sort | from i klebsiella pneumoniae i colonization to dissemination an overview of studies implementing murine models |
| topic | <i>Klebsiella pneumoniae</i> in vivo murine models colonization and virulence factors new therapeutics |
| url | https://www.mdpi.com/2076-2607/9/6/1282 |
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