Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as defining pathological features. AD presents a serious global health concern with no cure to date, refl...

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Bibliographic Details
Main Authors: Yam Nath Paudel, Efthalia Angelopoulou, Christina Piperi, Iekhsan Othman, Khurram Aamir, Mohd. Farooq Shaikh
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
hmgb1
alzheimer’s disease
rage
tlr4
neuroinflammation
Online Access:https://www.mdpi.com/2073-4409/9/2/383

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