Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study
Background: Recent studies have shown an association between weight change and the makeup of the intestinal microbiota in humans. Specifically, Lactobacillus, a part of the entire gastrointestinal tract's microbiota, has been shown to contribute to weight regulation. Aim: We examined the associ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-10-01
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| Series: | Obesity Facts |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/478095 |
| _version_ | 1818846064060399616 |
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| author | Johanne Aviaja Rosing Karen Christina Walker Benjamin A.H. Jensen Berit L. Heitmann |
| author_facet | Johanne Aviaja Rosing Karen Christina Walker Benjamin A.H. Jensen Berit L. Heitmann |
| author_sort | Johanne Aviaja Rosing |
| collection | DOAJ |
| description | Background: Recent studies have shown an association between weight change and the makeup of the intestinal microbiota in humans. Specifically, Lactobacillus, a part of the entire gastrointestinal tract's microbiota, has been shown to contribute to weight regulation. Aim: We examined the association between the level of oral Lactobacillus and the subsequent 6-year weight change in a healthy population of 322 Danish adults aged 35-65 years at baseline. Design: Prospective observational study. Results: In unadjusted analysis the level of oral Lactobacillus was inversely associated with subsequent 6-year change in BMI. A statistically significant interaction between the baseline level of oral Lactobacillus and the consumption of complex carbohydrates was found, e.g. high oral Lactobacillus count predicted weight loss for those with a low intake of complex carbohydrates, while a medium intake of complex carbohydrates predicted diminished weight gain. A closer examination of these relations showed that BMI change and Lactobacillus level was unrelated for those with high complex carbohydrate consumption. Conclusion: A high level of oral Lactobacillus seems related to weight loss among those with medium and low intakes of complex carbohydrates. Absence, or a low level of oral Lactobacillus, may potentially be a novel marker to identify those at increased risk of weight gain. |
| first_indexed | 2024-12-19T05:39:36Z |
| format | Article |
| id | doaj.art-a682e2eb48e847e9965d57d4bf0d5bc7 |
| institution | Directory Open Access Journal |
| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-19T05:39:36Z |
| publishDate | 2017-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-a682e2eb48e847e9965d57d4bf0d5bc72022-12-21T20:34:03ZengKarger PublishersObesity Facts1662-40251662-40332017-10-0110547348210.1159/000478095478095Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up StudyJohanne Aviaja RosingKaren Christina WalkerBenjamin A.H. JensenBerit L. HeitmannBackground: Recent studies have shown an association between weight change and the makeup of the intestinal microbiota in humans. Specifically, Lactobacillus, a part of the entire gastrointestinal tract's microbiota, has been shown to contribute to weight regulation. Aim: We examined the association between the level of oral Lactobacillus and the subsequent 6-year weight change in a healthy population of 322 Danish adults aged 35-65 years at baseline. Design: Prospective observational study. Results: In unadjusted analysis the level of oral Lactobacillus was inversely associated with subsequent 6-year change in BMI. A statistically significant interaction between the baseline level of oral Lactobacillus and the consumption of complex carbohydrates was found, e.g. high oral Lactobacillus count predicted weight loss for those with a low intake of complex carbohydrates, while a medium intake of complex carbohydrates predicted diminished weight gain. A closer examination of these relations showed that BMI change and Lactobacillus level was unrelated for those with high complex carbohydrate consumption. Conclusion: A high level of oral Lactobacillus seems related to weight loss among those with medium and low intakes of complex carbohydrates. Absence, or a low level of oral Lactobacillus, may potentially be a novel marker to identify those at increased risk of weight gain.https://www.karger.com/Article/FullText/478095ObesityHuman gutLactobacillusWeight changeProspective observational study |
| spellingShingle | Johanne Aviaja Rosing Karen Christina Walker Benjamin A.H. Jensen Berit L. Heitmann Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study Obesity Facts Obesity Human gut Lactobacillus Weight change Prospective observational study |
| title | Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study |
| title_full | Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study |
| title_fullStr | Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study |
| title_full_unstemmed | Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study |
| title_short | Oral Lactobacillus Counts Predict Weight Gain Susceptibility: A 6-Year Follow-Up Study |
| title_sort | oral lactobacillus counts predict weight gain susceptibility a 6 year follow up study |
| topic | Obesity Human gut Lactobacillus Weight change Prospective observational study |
| url | https://www.karger.com/Article/FullText/478095 |
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