Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021
The Shuni virus (SHUV) causes an endemic viral infection in Israel and South Africa. It belongs to the Simbu serogroup within the order <i>Bunyavirales</i>, family <i>Peribunyaviridae</i>, genus <i>Orthobunyavirus</i>. Recently, it has been identified in aborted c...
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| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/7/10/297 |
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| author | Natalia Golender Joseph Seffi Varsano Tomer Nissimyan Eitan Tiomkin |
| author_facet | Natalia Golender Joseph Seffi Varsano Tomer Nissimyan Eitan Tiomkin |
| author_sort | Natalia Golender |
| collection | DOAJ |
| description | The Shuni virus (SHUV) causes an endemic viral infection in Israel and South Africa. It belongs to the Simbu serogroup within the order <i>Bunyavirales</i>, family <i>Peribunyaviridae</i>, genus <i>Orthobunyavirus</i>. Recently, it has been identified in aborted cases of domestic ruminants, young cattle and horses manifesting neural signs and acute death, symptomatic cows, and in carcasses of wild animals. Moreover, SHUV was isolated and identified in humans. In this study, we describe clinical cases of SHUV infection in Israeli domestic ruminants in 2020–2021, which represented clinical manifestations of simbuviral infection including abortions, a neural lethal case in a fattening calf, and an acute symptomatic case in a beef cow. In all cases, SHUV was confirmed by complete or partial viral genome sequencing. There is a significant difference of M and L segments of the novel strains compared with those of all known SHUV strains, while the S segments have more than 99% nucleotide (nt) identity with Israeli and African “Israeli-like” strains previously circulated in 2014–2019. This indicates a reassortment origin of the strain. At the same time, M and S segment nt sequences showed about 98–99% nt identity with some South African strains collected in 2016–2018. Nevertheless, the viral origin and the geographical place of the reassortment stayed unknown. |
| first_indexed | 2024-03-09T19:25:05Z |
| format | Article |
| id | doaj.art-a6856dcefc0f4c89ac271d80690c4df8 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-09T19:25:05Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-a6856dcefc0f4c89ac271d80690c4df82023-11-24T03:00:35ZengMDPI AGTropical Medicine and Infectious Disease2414-63662022-10-0171029710.3390/tropicalmed7100297Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021Natalia Golender0Joseph Seffi Varsano1Tomer Nissimyan2Eitan Tiomkin3Department of Virology, Kimron Veterinary Institute, Bet Dagan 5025000, IsraelIndi-Vet Ltd., Ashdod 7764933, IsraelPublic Health Expert Ltd., Meishar 7685000, IsraelHachaklait Veterinary Services, Caesarea 3088900, IsraelThe Shuni virus (SHUV) causes an endemic viral infection in Israel and South Africa. It belongs to the Simbu serogroup within the order <i>Bunyavirales</i>, family <i>Peribunyaviridae</i>, genus <i>Orthobunyavirus</i>. Recently, it has been identified in aborted cases of domestic ruminants, young cattle and horses manifesting neural signs and acute death, symptomatic cows, and in carcasses of wild animals. Moreover, SHUV was isolated and identified in humans. In this study, we describe clinical cases of SHUV infection in Israeli domestic ruminants in 2020–2021, which represented clinical manifestations of simbuviral infection including abortions, a neural lethal case in a fattening calf, and an acute symptomatic case in a beef cow. In all cases, SHUV was confirmed by complete or partial viral genome sequencing. There is a significant difference of M and L segments of the novel strains compared with those of all known SHUV strains, while the S segments have more than 99% nucleotide (nt) identity with Israeli and African “Israeli-like” strains previously circulated in 2014–2019. This indicates a reassortment origin of the strain. At the same time, M and S segment nt sequences showed about 98–99% nt identity with some South African strains collected in 2016–2018. Nevertheless, the viral origin and the geographical place of the reassortment stayed unknown.https://www.mdpi.com/2414-6366/7/10/297simbuviruses<i>Orthobunyavirus</i><i>Peribunyaviridae</i>neurological signscattlesheep |
| spellingShingle | Natalia Golender Joseph Seffi Varsano Tomer Nissimyan Eitan Tiomkin Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 Tropical Medicine and Infectious Disease simbuviruses <i>Orthobunyavirus</i> <i>Peribunyaviridae</i> neurological signs cattle sheep |
| title | Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 |
| title_full | Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 |
| title_fullStr | Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 |
| title_full_unstemmed | Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 |
| title_short | Identification of Novel Reassortant Shuni Virus Strain in Clinical Cases of Israeli Ruminants, 2020–2021 |
| title_sort | identification of novel reassortant shuni virus strain in clinical cases of israeli ruminants 2020 2021 |
| topic | simbuviruses <i>Orthobunyavirus</i> <i>Peribunyaviridae</i> neurological signs cattle sheep |
| url | https://www.mdpi.com/2414-6366/7/10/297 |
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