Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort
Background: Bisphenol A (BPA) is known as an obesogenic endocrine disruptor. Bisphenol S (BPS) and F (BPF) are substitutes that have recently replaced BPA. Objectives: To investigate the relationships of urinary bisphenols (BPA, BPS and BPF) with adiposity measurements (obesity, BMI z-score, and fat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024001508 |
| _version_ | 1827311225208307712 |
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| author | Hye Jin Lee Yun Jeong Lee Youn-Hee Lim Hwa Young Kim Bung-Nyun Kim Johanna Inhyang Kim Yong Min Cho Yun-Chul Hong Choong Ho Shin Young Ah Lee |
| author_facet | Hye Jin Lee Yun Jeong Lee Youn-Hee Lim Hwa Young Kim Bung-Nyun Kim Johanna Inhyang Kim Yong Min Cho Yun-Chul Hong Choong Ho Shin Young Ah Lee |
| author_sort | Hye Jin Lee |
| collection | DOAJ |
| description | Background: Bisphenol A (BPA) is known as an obesogenic endocrine disruptor. Bisphenol S (BPS) and F (BPF) are substitutes that have recently replaced BPA. Objectives: To investigate the relationships of urinary bisphenols (BPA, BPS and BPF) with adiposity measurements (obesity, BMI z-score, and fat mass), serum adipokine levels (adiponectin and leptin), and adiponectin/leptin ratio (A/L ratio) in 6- and 8-year-old children. Methods: A total of 561 children who participated in the Environment and Development of Children cohort (482 and 516 children visited at age 6 and 8, respectively) at Seoul National University Children’s Hospital during 2015–2019 were included. Urinary BPA levels were log-transformed. BPS levels were categorized into three groups (non-detected, lower-half, and higher-half of detected), and BPF levels were classified into two groups (non-detected and detected). Results: The urinary BPS higher-half group had a higher BMI z-score (β = 0.160, P = 0.044), higher fat mass (β = 0.104, P < 0.001), lower adiponectin concentration (β =- 0.069, P < 0.001), higher leptin concentration (β = 0.360, P < 0.001), and lower A/L ratio (β =- 0.428, P < 0.001) compared with the non-detected group. The urinary BPF-detected group had a higher fat mass (β = 0.074, P < 0.001), lower adiponectin concentration (β =- 0.069, P < 0.001), higher leptin concentration (β = 0.360, P < 0.001), and lower A/L ratio (β =- 0.428, P < 0.001) compared with the non-detected group. The BPA levels showed no consistent associations with outcomes, except for isolated associations of BPA at age 6 with a higher BMI z-score at age 6 (P = 0.016) and leptin at age 8 (P = 0.021). Conclusions: Increased exposure to BPS and BPF is associated with higher fat mass and leptin concentration, lower serum adiponectin, and lower A/L ratio in children. These findings suggest potential adverse effects of BPA substitutes on adiposity and adipokines. No consistent association of BPA exposure with outcomes could be partly explained by the decreasing BPA levels over time. |
| first_indexed | 2024-04-24T20:14:28Z |
| format | Article |
| id | doaj.art-a6860b51df9143a9a856b2e1a0ffb3e8 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-24T20:14:28Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-a6860b51df9143a9a856b2e1a0ffb3e82024-03-23T06:22:23ZengElsevierEnvironment International0160-41202024-03-01185108564Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohortHye Jin Lee0Yun Jeong Lee1Youn-Hee Lim2Hwa Young Kim3Bung-Nyun Kim4Johanna Inhyang Kim5Yong Min Cho6Yun-Chul Hong7Choong Ho Shin8Young Ah Lee9Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Pediatrics, Bundang Seoul National University Hospital, Republic of KoreaDivision of Children and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Psychiatry, Hanyang University College of Medicine, Seoul, Republic of KoreaDepartment of Nano Chemical and Biological Engineering, SeoKyeong University, Seoul, Republic of KoreaInstitute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea; Corresponding author at: Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-Gu, Seoul 03080, Seoul, Republic of Korea.Background: Bisphenol A (BPA) is known as an obesogenic endocrine disruptor. Bisphenol S (BPS) and F (BPF) are substitutes that have recently replaced BPA. Objectives: To investigate the relationships of urinary bisphenols (BPA, BPS and BPF) with adiposity measurements (obesity, BMI z-score, and fat mass), serum adipokine levels (adiponectin and leptin), and adiponectin/leptin ratio (A/L ratio) in 6- and 8-year-old children. Methods: A total of 561 children who participated in the Environment and Development of Children cohort (482 and 516 children visited at age 6 and 8, respectively) at Seoul National University Children’s Hospital during 2015–2019 were included. Urinary BPA levels were log-transformed. BPS levels were categorized into three groups (non-detected, lower-half, and higher-half of detected), and BPF levels were classified into two groups (non-detected and detected). Results: The urinary BPS higher-half group had a higher BMI z-score (β = 0.160, P = 0.044), higher fat mass (β = 0.104, P < 0.001), lower adiponectin concentration (β =- 0.069, P < 0.001), higher leptin concentration (β = 0.360, P < 0.001), and lower A/L ratio (β =- 0.428, P < 0.001) compared with the non-detected group. The urinary BPF-detected group had a higher fat mass (β = 0.074, P < 0.001), lower adiponectin concentration (β =- 0.069, P < 0.001), higher leptin concentration (β = 0.360, P < 0.001), and lower A/L ratio (β =- 0.428, P < 0.001) compared with the non-detected group. The BPA levels showed no consistent associations with outcomes, except for isolated associations of BPA at age 6 with a higher BMI z-score at age 6 (P = 0.016) and leptin at age 8 (P = 0.021). Conclusions: Increased exposure to BPS and BPF is associated with higher fat mass and leptin concentration, lower serum adiponectin, and lower A/L ratio in children. These findings suggest potential adverse effects of BPA substitutes on adiposity and adipokines. No consistent association of BPA exposure with outcomes could be partly explained by the decreasing BPA levels over time.http://www.sciencedirect.com/science/article/pii/S0160412024001508Bisphenol ABisphenol SBisphenol FObesityAdiponectinLeptin |
| spellingShingle | Hye Jin Lee Yun Jeong Lee Youn-Hee Lim Hwa Young Kim Bung-Nyun Kim Johanna Inhyang Kim Yong Min Cho Yun-Chul Hong Choong Ho Shin Young Ah Lee Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort Environment International Bisphenol A Bisphenol S Bisphenol F Obesity Adiponectin Leptin |
| title | Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort |
| title_full | Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort |
| title_fullStr | Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort |
| title_full_unstemmed | Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort |
| title_short | Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort |
| title_sort | relationship of bisphenol a substitutes bisphenol f and bisphenol s with adiponectin leptin ratio among children from the environment and development of children cohort |
| topic | Bisphenol A Bisphenol S Bisphenol F Obesity Adiponectin Leptin |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024001508 |
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