Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections

Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections

Our recent focus on the “lost antibiotic” unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against <i>Staphylococcus aureus</i> isolates either susceptible or resistant to methicil...

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Bibliographic Details
Main Authors: Hang Thi Nguyen, Mahmud T. Morshed, Daniel Vuong, Andrew Crombie, Ernest Lacey, Sanjay Garg, Hongfei Pi, Lucy Woolford, Henrietta Venter, Stephen W. Page, Andrew M. Piggott, Darren J. Trott, Abiodun D. Ogunniyi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antibiotics
Subjects:
<i>Staphylococcus pseudintermedius</i>
<i>Staphylococcus aureus</i>
benzguinols
nidulins
Gram-negative
antimicrobial resistance
Online Access:https://www.mdpi.com/2079-6382/10/6/727

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