The level of galectin-3 in the blood serum of patients with chronic hepatitis C
Aim. to assess galectin-3 level in the serum of HCV patients according to the biochemical activity of hepatitis, liver fibrosis, in view of insulin resistance and overweight.Materials and methods: The content of serum galectin-3 was detected in 78 patients with chronic hepatitis C in age from 20 to...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2016-07-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/484 |
| _version_ | 1826557852137816064 |
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| author | V. A. Kovalevа N. S. Zhevnerova T. V. Antonova |
| author_facet | V. A. Kovalevа N. S. Zhevnerova T. V. Antonova |
| author_sort | V. A. Kovalevа |
| collection | DOAJ |
| description | Aim. to assess galectin-3 level in the serum of HCV patients according to the biochemical activity of hepatitis, liver fibrosis, in view of insulin resistance and overweight.Materials and methods: The content of serum galectin-3 was detected in 78 patients with chronic hepatitis C in age from 20 to 55 years with oligosymptomatic course of the disease and minimally expressed liver fibrosis in most cases. We evaluated the association between the content of galectin-3 in the blood and metabolic disorders, biochemical activity of hepatitis and fibrosis of the liver.Results: In patients with normal ALT levels (42% of the patients), the average level of galectin was 3.17 (1.23; 5.94) ng / ml. Elevated levels of gammaglobulin in blood was noted in 21 patients, 15 of them also had elevated levels of galectin-3. Patients infected with genotype 1b, galectin-3 was higher than other genotypes. With a high viral load (> 500,000 IU / mL), the average level of galectin-3 was higher than the lowest. One-third of patients with overweight levels of galectin-3 was higher than normal. MI was diagnosed in the majority (61.5%) examinees, and in these patients, there was an increase level of galectin-3. When comparing the levels of galectin in patients with varying degrees of fibrosis, significant differences were found only when F0 – F2 (p = 0,033).Conclusion: The galectin-3 serum level was elevated in most patients with chronic hepatitis C. The maximum increase in galectin-3 was observed in patients with severe liver fibrosis (F 3). The connection between the level of galectin-3 and the metabolic syndrome components such as body mass index, and insulin resistance was found. |
| first_indexed | 2024-03-12T04:46:12Z |
| format | Article |
| id | doaj.art-a686f705360d4615a19cde7643f929ac |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2025-03-14T08:35:10Z |
| publishDate | 2016-07-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-a686f705360d4615a19cde7643f929ac2025-03-02T13:00:28ZrusJournal InfectologyЖурнал инфектологии2072-67322016-07-01828591481The level of galectin-3 in the blood serum of patients with chronic hepatitis CV. A. Kovalevа0N. S. Zhevnerova1T. V. Antonova2The First Saint-Petersburg State Medical University named after academician I.P. PavlovThe First Saint-Petersburg State Medical University named after academician I.P. PavlovThe First Saint-Petersburg State Medical University named after academician I.P. PavlovAim. to assess galectin-3 level in the serum of HCV patients according to the biochemical activity of hepatitis, liver fibrosis, in view of insulin resistance and overweight.Materials and methods: The content of serum galectin-3 was detected in 78 patients with chronic hepatitis C in age from 20 to 55 years with oligosymptomatic course of the disease and minimally expressed liver fibrosis in most cases. We evaluated the association between the content of galectin-3 in the blood and metabolic disorders, biochemical activity of hepatitis and fibrosis of the liver.Results: In patients with normal ALT levels (42% of the patients), the average level of galectin was 3.17 (1.23; 5.94) ng / ml. Elevated levels of gammaglobulin in blood was noted in 21 patients, 15 of them also had elevated levels of galectin-3. Patients infected with genotype 1b, galectin-3 was higher than other genotypes. With a high viral load (> 500,000 IU / mL), the average level of galectin-3 was higher than the lowest. One-third of patients with overweight levels of galectin-3 was higher than normal. MI was diagnosed in the majority (61.5%) examinees, and in these patients, there was an increase level of galectin-3. When comparing the levels of galectin in patients with varying degrees of fibrosis, significant differences were found only when F0 – F2 (p = 0,033).Conclusion: The galectin-3 serum level was elevated in most patients with chronic hepatitis C. The maximum increase in galectin-3 was observed in patients with severe liver fibrosis (F 3). The connection between the level of galectin-3 and the metabolic syndrome components such as body mass index, and insulin resistance was found.https://journal.niidi.ru/jofin/article/view/484chronic hepatitis cgalectin-3liver fibrosisinsulin resistancemetabolic syndrome |
| spellingShingle | V. A. Kovalevа N. S. Zhevnerova T. V. Antonova The level of galectin-3 in the blood serum of patients with chronic hepatitis C Журнал инфектологии chronic hepatitis c galectin-3 liver fibrosis insulin resistance metabolic syndrome |
| title | The level of galectin-3 in the blood serum of patients with chronic hepatitis C |
| title_full | The level of galectin-3 in the blood serum of patients with chronic hepatitis C |
| title_fullStr | The level of galectin-3 in the blood serum of patients with chronic hepatitis C |
| title_full_unstemmed | The level of galectin-3 in the blood serum of patients with chronic hepatitis C |
| title_short | The level of galectin-3 in the blood serum of patients with chronic hepatitis C |
| title_sort | level of galectin 3 in the blood serum of patients with chronic hepatitis c |
| topic | chronic hepatitis c galectin-3 liver fibrosis insulin resistance metabolic syndrome |
| url | https://journal.niidi.ru/jofin/article/view/484 |
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