Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer
Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523004872 |
| Summary: | Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparticle via hydrophobic interactions and coordination interactions to achieve chemotherapy (CT) and chemodynamic therapy (CDT). PEG-DOX@Cu accumulated in tumour tissue and released DOX and Cu2+ into the tumour microenvironment. Cu2+ reacted with GSH to form Cu+. Cu+ continued to react with H2O2 to form •OH. DOX killed lung cancer cells and activated NOX4, up-regulating the endogenous H2O2 level and further enhancing the efficiency of CDT. In vitro and in vivo experiments demonstrated that PEG-DOX@Cu has superior biological safety and can inhibit the growth of lung cancer tumours via synergistic CT/CDT. This research offers a new strategy for the construction of metal-phenolic network nanoparticles for the synergistic treatment of lung cancer by CT/CDT. |
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| ISSN: | 0264-1275 |