Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer
Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523004872 |
| _version_ | 1797794018577350656 |
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| author | Daiwang Shi Siyi Li Wenhan Liu Liang Song Ran Xu |
| author_facet | Daiwang Shi Siyi Li Wenhan Liu Liang Song Ran Xu |
| author_sort | Daiwang Shi |
| collection | DOAJ |
| description | Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparticle via hydrophobic interactions and coordination interactions to achieve chemotherapy (CT) and chemodynamic therapy (CDT). PEG-DOX@Cu accumulated in tumour tissue and released DOX and Cu2+ into the tumour microenvironment. Cu2+ reacted with GSH to form Cu+. Cu+ continued to react with H2O2 to form •OH. DOX killed lung cancer cells and activated NOX4, up-regulating the endogenous H2O2 level and further enhancing the efficiency of CDT. In vitro and in vivo experiments demonstrated that PEG-DOX@Cu has superior biological safety and can inhibit the growth of lung cancer tumours via synergistic CT/CDT. This research offers a new strategy for the construction of metal-phenolic network nanoparticles for the synergistic treatment of lung cancer by CT/CDT. |
| first_indexed | 2024-03-13T02:56:45Z |
| format | Article |
| id | doaj.art-a687b02530ed44a59d445c22f3a33ca4 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-13T02:56:45Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-a687b02530ed44a59d445c22f3a33ca42023-06-28T04:28:43ZengElsevierMaterials & Design0264-12752023-07-01231112072Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancerDaiwang Shi0Siyi Li1Wenhan Liu2Liang Song3Ran Xu4Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaCorresponding author.; Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaLung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparticle via hydrophobic interactions and coordination interactions to achieve chemotherapy (CT) and chemodynamic therapy (CDT). PEG-DOX@Cu accumulated in tumour tissue and released DOX and Cu2+ into the tumour microenvironment. Cu2+ reacted with GSH to form Cu+. Cu+ continued to react with H2O2 to form •OH. DOX killed lung cancer cells and activated NOX4, up-regulating the endogenous H2O2 level and further enhancing the efficiency of CDT. In vitro and in vivo experiments demonstrated that PEG-DOX@Cu has superior biological safety and can inhibit the growth of lung cancer tumours via synergistic CT/CDT. This research offers a new strategy for the construction of metal-phenolic network nanoparticles for the synergistic treatment of lung cancer by CT/CDT.http://www.sciencedirect.com/science/article/pii/S0264127523004872Metal-phenolic networkpH-SensitiveControlled drugs releaseChemo/chemodynamic therapyLung cancer |
| spellingShingle | Daiwang Shi Siyi Li Wenhan Liu Liang Song Ran Xu Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer Materials & Design Metal-phenolic network pH-Sensitive Controlled drugs release Chemo/chemodynamic therapy Lung cancer |
| title | Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer |
| title_full | Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer |
| title_fullStr | Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer |
| title_full_unstemmed | Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer |
| title_short | Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer |
| title_sort | metal phenolic network ph sensitive nanoparticle enabled chemo chemodynamic therapy for lung cancer |
| topic | Metal-phenolic network pH-Sensitive Controlled drugs release Chemo/chemodynamic therapy Lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523004872 |
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