Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine
Silk sericin (SS) produced by <i>Bombyx mori</i> is normally discarded as waste in manufacturing processes, which causes environmental pollution. Therefore, investigating the use of silk sericin has economic and environmental benefits. As a three-dimensional structure, the sericin-derive...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/7/1/23 |
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| author | Chi Yan Jianwei Liang Hao Fang Xizhi Meng Jiale Chen Zhi Zhong Qin Liu Hongmei Hu Xiaoning Zhang |
| author_facet | Chi Yan Jianwei Liang Hao Fang Xizhi Meng Jiale Chen Zhi Zhong Qin Liu Hongmei Hu Xiaoning Zhang |
| author_sort | Chi Yan |
| collection | DOAJ |
| description | Silk sericin (SS) produced by <i>Bombyx mori</i> is normally discarded as waste in manufacturing processes, which causes environmental pollution. Therefore, investigating the use of silk sericin has economic and environmental benefits. As a three-dimensional structure, the sericin-derived hydrogel was explored in different applications. However, many developed gelation procedures raise concerns regarding safety, cost, and duration of gelation time. In this work, “thiol-ene” click chemistry was used to quickly and controllably prepare an SS-derived hydrogel to resolve these early concerns. Then, berberine was loaded and used as a model for investigating the drug-release profiles of the prepared hydrogel. The experimental results revealed that this hydrogel is eligible for a long-term release of berberine. Throughout the antibacterial experiments, the released berberine maintained its antibacterial activity. Our work expands the application of SS in biomedical industries in an eco-friendly way. Furthermore, the discussed strategy could provide a reference for the subsequent development of SS-derived materials. |
| first_indexed | 2024-03-09T00:41:52Z |
| format | Article |
| id | doaj.art-a687dc81b3e84c10a2f9a9f38dd15eee |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T00:41:52Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-a687dc81b3e84c10a2f9a9f38dd15eee2023-12-11T17:48:48ZengMDPI AGGels2310-28612021-02-01712310.3390/gels7010023Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug BerberineChi Yan0Jianwei Liang1Hao Fang2Xizhi Meng3Jiale Chen4Zhi Zhong5Qin Liu6Hongmei Hu7Xiaoning Zhang8State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaKey Laboratory of Mariculture and Enhancement of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, ChinaKey Laboratory of Mariculture and Enhancement of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, ChinaKey Laboratory of Mariculture and Enhancement of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, ChinaState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaSilk sericin (SS) produced by <i>Bombyx mori</i> is normally discarded as waste in manufacturing processes, which causes environmental pollution. Therefore, investigating the use of silk sericin has economic and environmental benefits. As a three-dimensional structure, the sericin-derived hydrogel was explored in different applications. However, many developed gelation procedures raise concerns regarding safety, cost, and duration of gelation time. In this work, “thiol-ene” click chemistry was used to quickly and controllably prepare an SS-derived hydrogel to resolve these early concerns. Then, berberine was loaded and used as a model for investigating the drug-release profiles of the prepared hydrogel. The experimental results revealed that this hydrogel is eligible for a long-term release of berberine. Throughout the antibacterial experiments, the released berberine maintained its antibacterial activity. Our work expands the application of SS in biomedical industries in an eco-friendly way. Furthermore, the discussed strategy could provide a reference for the subsequent development of SS-derived materials.https://www.mdpi.com/2310-2861/7/1/23silk sericinthiol-enehydrogeldrug delivery |
| spellingShingle | Chi Yan Jianwei Liang Hao Fang Xizhi Meng Jiale Chen Zhi Zhong Qin Liu Hongmei Hu Xiaoning Zhang Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine Gels silk sericin thiol-ene hydrogel drug delivery |
| title | Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine |
| title_full | Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine |
| title_fullStr | Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine |
| title_full_unstemmed | Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine |
| title_short | Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine |
| title_sort | fabrication and evaluation of silk sericin derived hydrogel for the release of the model drug berberine |
| topic | silk sericin thiol-ene hydrogel drug delivery |
| url | https://www.mdpi.com/2310-2861/7/1/23 |
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