Th1/Th2 differentiation and B cell function by the atypical PKCs and their regulators

Th1/Th2 differentiation and B cell function by the atypical PKCs and their regulators

The members of the atypical PKCs (aPKC) kinase subfamily, PKCζ and PKCλ/ι, as well as their adapters, p62 and Par-6, form part of the PB1-domain-containing group of signaling regulators. Both adapters serve to locate through heterotypic interactions the aPKCs into the NF-κB and cell polarity pathway...

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Bibliographic Details
Main Authors: Pilar eMartin, Jorge eMoscat
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Asthma
STAT6
NF-KappaB
th2
atypical PKC
p62
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00241/full

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