Serum trypsin inhibitory capacity in hemodialysis patients
It has been established that overproduction of reactive oxygen species (ROS) occurs during hemodialysis causing oxidation of proteins. Alpha-1-antitrypsin is the major circulating anti-protease which contains methionine in the active site. The aim of the present study was to measure the level of ser...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Subjects: | |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=4;spage=604;epage=607;aulast=Hashemi |
| _version_ | 1818419100285665280 |
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| author | Hashemi Mohammad Mehrabifar Hamid Homayooni Fatemeh Naderi Mohammad Montazerifar Farzaneh Ghavami Saeid |
| author_facet | Hashemi Mohammad Mehrabifar Hamid Homayooni Fatemeh Naderi Mohammad Montazerifar Farzaneh Ghavami Saeid |
| author_sort | Hashemi Mohammad |
| collection | DOAJ |
| description | It has been established that overproduction of reactive oxygen species (ROS) occurs during hemodialysis causing oxidation of proteins. Alpha-1-antitrypsin is the major circulating anti-protease which contains methionine in the active site. The aim of the present study was to measure the level of serum trypsin inhibitory capacity (sTIC) in hemodialysis patients. This case-control study was performed in 52 hemodialysis patients and 49 healthy controls. sTIC was measured by enzymatic assay. The sTIC was significantly (P< 0.001) lower in hemodialysis patients (1.87 ± 0.67 µmol/min/mL) than healthy controls (2.83 ± 0.44 µmol/min/L). Reduction of sTIC may be due to the oxidation of methionine residue in the reactive site of alpha-1 antitrypsin. |
| first_indexed | 2024-12-14T12:33:12Z |
| format | Article |
| id | doaj.art-a68ca68761ae4d13adc5311c1059cc00 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-14T12:33:12Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-a68ca68761ae4d13adc5311c1059cc002022-12-21T23:01:08ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422009-01-01204604607Serum trypsin inhibitory capacity in hemodialysis patientsHashemi MohammadMehrabifar HamidHomayooni FatemehNaderi MohammadMontazerifar FarzanehGhavami SaeidIt has been established that overproduction of reactive oxygen species (ROS) occurs during hemodialysis causing oxidation of proteins. Alpha-1-antitrypsin is the major circulating anti-protease which contains methionine in the active site. The aim of the present study was to measure the level of serum trypsin inhibitory capacity (sTIC) in hemodialysis patients. This case-control study was performed in 52 hemodialysis patients and 49 healthy controls. sTIC was measured by enzymatic assay. The sTIC was significantly (P< 0.001) lower in hemodialysis patients (1.87 ± 0.67 µmol/min/mL) than healthy controls (2.83 ± 0.44 µmol/min/L). Reduction of sTIC may be due to the oxidation of methionine residue in the reactive site of alpha-1 antitrypsin.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=4;spage=604;epage=607;aulast=HashemiAlpha-1 AnitrypsinHemodialysisChronic renal failureSerum trypsin inhibitory capacity |
| spellingShingle | Hashemi Mohammad Mehrabifar Hamid Homayooni Fatemeh Naderi Mohammad Montazerifar Farzaneh Ghavami Saeid Serum trypsin inhibitory capacity in hemodialysis patients Saudi Journal of Kidney Diseases and Transplantation Alpha-1 Anitrypsin Hemodialysis Chronic renal failure Serum trypsin inhibitory capacity |
| title | Serum trypsin inhibitory capacity in hemodialysis patients |
| title_full | Serum trypsin inhibitory capacity in hemodialysis patients |
| title_fullStr | Serum trypsin inhibitory capacity in hemodialysis patients |
| title_full_unstemmed | Serum trypsin inhibitory capacity in hemodialysis patients |
| title_short | Serum trypsin inhibitory capacity in hemodialysis patients |
| title_sort | serum trypsin inhibitory capacity in hemodialysis patients |
| topic | Alpha-1 Anitrypsin Hemodialysis Chronic renal failure Serum trypsin inhibitory capacity |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=4;spage=604;epage=607;aulast=Hashemi |
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