SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS
The dermatophytosis treatment in dogs can fail due to dermatophyte resistance to antifungals. The purpose of this study is to determine the antifungal sensitivity of dermatophyte Microsporum canis (M. canis) isolated from dogs with dermatophyte. A total of 17 M. canis dog isolates were tested for s...
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| Format: | Article |
| Language: | English |
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Universitas Syiah Kuala
2021-02-01
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| Series: | Jurnal Kedokteran Hewan |
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| Online Access: | https://jurnal.usk.ac.id/JKH/article/view/17617 |
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| author | Gerson Yohanes I Sakan Soedarmanto Indarjulianto Alfarisa Nururrozi Yanuartono Yanuartono Slamet Raharjo |
| author_facet | Gerson Yohanes I Sakan Soedarmanto Indarjulianto Alfarisa Nururrozi Yanuartono Yanuartono Slamet Raharjo |
| author_sort | Gerson Yohanes I Sakan |
| collection | DOAJ |
| description | The dermatophytosis treatment in dogs can fail due to dermatophyte resistance to antifungals. The purpose of this study is to determine the
antifungal sensitivity of dermatophyte Microsporum canis (M. canis) isolated from dogs with dermatophyte. A total of 17 M. canis dog isolates
were tested for sensitivity to 25 µg fluconazole, 25 µg griseofulvin, 15 µg ketoconazole and 30 µg terbinafine, using the disc diffusion method.
The M. canis isolates were cultured on Sabouraud's Dextrose Agar media, placed an antifungal disc, and then incubated at 28 C for 7 days. The
diameter of inhibition zone was measured, then compared with the standard, to determine whether they were sensitive, intermediate or resistant.
The results of this study indicate that 16 isolates were sensitive to fluconazole; 17 isolates were sensitive to griseofulvin, ketoconazole and
terbinafine; and one isolate was intermediate to fluconazole. Based on these results, it is concluded that all 17 (100%) isolates are sensitive to the
antifungals griseofulvin, ketoconazole, terbinafine, and 16 (94%) isolates are sensitive to fluconazole. Thus, the four antifungals can be selected
to treat dermatophytes in dogs. |
| first_indexed | 2024-03-07T16:16:06Z |
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| id | doaj.art-a68db0646f184f4e9d569c3d65e9daa6 |
| institution | Directory Open Access Journal |
| issn | 1978-225X 2502-5600 |
| language | English |
| last_indexed | 2025-03-22T04:13:14Z |
| publishDate | 2021-02-01 |
| publisher | Universitas Syiah Kuala |
| record_format | Article |
| series | Jurnal Kedokteran Hewan |
| spelling | doaj.art-a68db0646f184f4e9d569c3d65e9daa62024-04-28T08:37:47ZengUniversitas Syiah KualaJurnal Kedokteran Hewan1978-225X2502-56002021-02-0114410811110.21157/j.ked.hewan.v14i4.1761712330SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALSGerson Yohanes I Sakan0Soedarmanto Indarjulianto1Alfarisa Nururrozi2Yanuartono Yanuartono3Slamet Raharjo4Animal Health Study Program, the State Agricultural Polytechnic of Kupang, IndonesiaDepartment of Internal Medicine, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.Department of Internal Medicine, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.Department of Internal Medicine, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.Department of Internal Medicine, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.The dermatophytosis treatment in dogs can fail due to dermatophyte resistance to antifungals. The purpose of this study is to determine the antifungal sensitivity of dermatophyte Microsporum canis (M. canis) isolated from dogs with dermatophyte. A total of 17 M. canis dog isolates were tested for sensitivity to 25 µg fluconazole, 25 µg griseofulvin, 15 µg ketoconazole and 30 µg terbinafine, using the disc diffusion method. The M. canis isolates were cultured on Sabouraud's Dextrose Agar media, placed an antifungal disc, and then incubated at 28 C for 7 days. The diameter of inhibition zone was measured, then compared with the standard, to determine whether they were sensitive, intermediate or resistant. The results of this study indicate that 16 isolates were sensitive to fluconazole; 17 isolates were sensitive to griseofulvin, ketoconazole and terbinafine; and one isolate was intermediate to fluconazole. Based on these results, it is concluded that all 17 (100%) isolates are sensitive to the antifungals griseofulvin, ketoconazole, terbinafine, and 16 (94%) isolates are sensitive to fluconazole. Thus, the four antifungals can be selected to treat dermatophytes in dogs.https://jurnal.usk.ac.id/JKH/article/view/17617antifungal sensitivity, dogs, griseofulvin, microsporum canis, terbinafine |
| spellingShingle | Gerson Yohanes I Sakan Soedarmanto Indarjulianto Alfarisa Nururrozi Yanuartono Yanuartono Slamet Raharjo SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS Jurnal Kedokteran Hewan antifungal sensitivity, dogs, griseofulvin, microsporum canis, terbinafine |
| title | SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS |
| title_full | SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS |
| title_fullStr | SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS |
| title_full_unstemmed | SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS |
| title_short | SENSITIVITY OF Microsporum canis ISOLATED FROM DOGS TOWARDS ANTIFUNGALS |
| title_sort | sensitivity of microsporum canis isolated from dogs towards antifungals |
| topic | antifungal sensitivity, dogs, griseofulvin, microsporum canis, terbinafine |
| url | https://jurnal.usk.ac.id/JKH/article/view/17617 |
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