Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012)
Current reports on prognostic factors for chondrosarcoma mainly involve patients in treatment centers. Few are based on multicenter or multi-eras. We analyzed existing data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the risk factors for survival outcomes. All...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-11-01
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| Series: | Journal of Bone Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137417301264 |
| _version_ | 1818904714265231360 |
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| author | Zhigang Nie Qiang Lu Hao Peng |
| author_facet | Zhigang Nie Qiang Lu Hao Peng |
| author_sort | Zhigang Nie |
| collection | DOAJ |
| description | Current reports on prognostic factors for chondrosarcoma mainly involve patients in treatment centers. Few are based on multicenter or multi-eras. We analyzed existing data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the risk factors for survival outcomes. All patients with chondrosarcoma from 1973 to 2012 were identified. 3737 patients were eligible and included. In survival analysis, patient had good survival outcome if the patient was female, young, with localized stage, well grade, small tumor size, treated with surgery, while patient was male, old, with distant stage, undifferentiated grade, tumor size <50 mm, located in vertebral or pelvic bones, underwent radiation had bad survival outcome. Surgery types from having best survival outcomes to worst were local excision, radical excision, amputation, no surgery. ‘Well’ and ‘moderately’ grade seems to be suitable for local excision, but ‘poorly’ and ‘undifferentiated’ grade suitable for wide local excision. Multivariate COX regression analysis showed year of diagnosis, sex, age of diagnosis, stage, grade, tumor site, surgery, radiation were independent risk factors. Year of diagnosis, sex, age of diagnosis, stage, grade, tumor site, surgery, radiation were independent risk factors. Excision is a better treatment than amputation. Doctors can use wide local excision to treat chondrosarcoma, especially when encountering high grade chondrosarcoma or pelvic chondrosarcoma. Key words: Chondrosarcoma, Incidence, Treatment, Outcomes |
| first_indexed | 2024-12-19T21:11:49Z |
| format | Article |
| id | doaj.art-a6925d7616564eabb31820a548bdd39b |
| institution | Directory Open Access Journal |
| issn | 2212-1374 |
| language | English |
| last_indexed | 2024-12-19T21:11:49Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj.art-a6925d7616564eabb31820a548bdd39b2022-12-21T20:05:28ZengElsevierJournal of Bone Oncology2212-13742018-11-01135561Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012)Zhigang Nie0Qiang Lu1Hao Peng2Department of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan 430060, Hubei, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan 430060, Hubei, ChinaCorresponding author.; Department of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan 430060, Hubei, ChinaCurrent reports on prognostic factors for chondrosarcoma mainly involve patients in treatment centers. Few are based on multicenter or multi-eras. We analyzed existing data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the risk factors for survival outcomes. All patients with chondrosarcoma from 1973 to 2012 were identified. 3737 patients were eligible and included. In survival analysis, patient had good survival outcome if the patient was female, young, with localized stage, well grade, small tumor size, treated with surgery, while patient was male, old, with distant stage, undifferentiated grade, tumor size <50 mm, located in vertebral or pelvic bones, underwent radiation had bad survival outcome. Surgery types from having best survival outcomes to worst were local excision, radical excision, amputation, no surgery. ‘Well’ and ‘moderately’ grade seems to be suitable for local excision, but ‘poorly’ and ‘undifferentiated’ grade suitable for wide local excision. Multivariate COX regression analysis showed year of diagnosis, sex, age of diagnosis, stage, grade, tumor site, surgery, radiation were independent risk factors. Year of diagnosis, sex, age of diagnosis, stage, grade, tumor site, surgery, radiation were independent risk factors. Excision is a better treatment than amputation. Doctors can use wide local excision to treat chondrosarcoma, especially when encountering high grade chondrosarcoma or pelvic chondrosarcoma. Key words: Chondrosarcoma, Incidence, Treatment, Outcomeshttp://www.sciencedirect.com/science/article/pii/S2212137417301264 |
| spellingShingle | Zhigang Nie Qiang Lu Hao Peng Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) Journal of Bone Oncology |
| title | Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) |
| title_full | Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) |
| title_fullStr | Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) |
| title_full_unstemmed | Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) |
| title_short | Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012) |
| title_sort | prognostic factors for patients with chondrosarcoma a survival analysis based on the surveillance epidemiology and end results seer database 1973 2012 |
| url | http://www.sciencedirect.com/science/article/pii/S2212137417301264 |
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