The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box
Since the pandemic started, the coronavirus disease 2019 (COVID-19) has spread worldwide. In patients with COVID-19, the gut microbiome (GM) has been supposed to be closely related to the progress of the disease. The gut microbiota composition and human genetic variation are also connected in COVID-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1190939/full |
| _version_ | 1797791825999691776 |
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| author | Jie Tong Jie Tong Yuran Chen Mei He Wenjing Wang Yiyang Wang Na Li Na Li Qianfeng Xia Qianfeng Xia |
| author_facet | Jie Tong Jie Tong Yuran Chen Mei He Wenjing Wang Yiyang Wang Na Li Na Li Qianfeng Xia Qianfeng Xia |
| author_sort | Jie Tong |
| collection | DOAJ |
| description | Since the pandemic started, the coronavirus disease 2019 (COVID-19) has spread worldwide. In patients with COVID-19, the gut microbiome (GM) has been supposed to be closely related to the progress of the disease. The gut microbiota composition and human genetic variation are also connected in COVID-19 patients, assuming a triangular relationship between the genome, GM, and COVID-19. Here, we reviewed the recent developments in the study of the relationship between gut microbiota and COVID-19. The keywords “COVID-19,” “microbiome,” and “genome” were used to search the literature in the PubMed database. We first found that the composition of the GM in COVID-19 patients varies according to the severity of the illness. Most obviously, Candida albicans abnormally increased while the probiotic Bifidobacterium decreased in severe cases of COVID-19. Interestingly, clinical studies have consistently emphasized that the family Lachnospiraceae plays a critical role in patients with COVID-19. Additionally, we have demonstrated the impact of microbiome-related genes on COVID-19. Specially, we focused on angiotensin-converting enzyme 2’s dual functions in SARS-CoV-2 infection and gut microbiota alternation. In summary, these studies showed that the diversity of GMs is closely connected to COVID-19. A triangular relationship exists between COVID-19, the human genome, and the gut flora, suggesting that human genetic variations may offer a chance for a precise diagnosis of COVID-19, and the important relationships between genetic makeup and microbiome regulation may affect the therapy of COVID-19. |
| first_indexed | 2024-03-13T02:24:19Z |
| format | Article |
| id | doaj.art-a692f8c7b3024d248bff0e723ee4b283 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T02:24:19Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a692f8c7b3024d248bff0e723ee4b2832023-06-30T05:53:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.11909391190939The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s boxJie Tong0Jie Tong1Yuran Chen2Mei He3Wenjing Wang4Yiyang Wang5Na Li6Na Li7Qianfeng Xia8Qianfeng Xia9Key Laboratory of Tropical Translational Medicine of Ministry of Education, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, ChinaCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, ChinaCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, ChinaCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, ChinaCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, ChinaCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, ChinaDepartment of Tropical Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, ChinaDepartment of Tropical Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaSince the pandemic started, the coronavirus disease 2019 (COVID-19) has spread worldwide. In patients with COVID-19, the gut microbiome (GM) has been supposed to be closely related to the progress of the disease. The gut microbiota composition and human genetic variation are also connected in COVID-19 patients, assuming a triangular relationship between the genome, GM, and COVID-19. Here, we reviewed the recent developments in the study of the relationship between gut microbiota and COVID-19. The keywords “COVID-19,” “microbiome,” and “genome” were used to search the literature in the PubMed database. We first found that the composition of the GM in COVID-19 patients varies according to the severity of the illness. Most obviously, Candida albicans abnormally increased while the probiotic Bifidobacterium decreased in severe cases of COVID-19. Interestingly, clinical studies have consistently emphasized that the family Lachnospiraceae plays a critical role in patients with COVID-19. Additionally, we have demonstrated the impact of microbiome-related genes on COVID-19. Specially, we focused on angiotensin-converting enzyme 2’s dual functions in SARS-CoV-2 infection and gut microbiota alternation. In summary, these studies showed that the diversity of GMs is closely connected to COVID-19. A triangular relationship exists between COVID-19, the human genome, and the gut flora, suggesting that human genetic variations may offer a chance for a precise diagnosis of COVID-19, and the important relationships between genetic makeup and microbiome regulation may affect the therapy of COVID-19.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1190939/fullCOVID-19genomegut microbiotainfectious diseasesSARS-CoV-2 |
| spellingShingle | Jie Tong Jie Tong Yuran Chen Mei He Wenjing Wang Yiyang Wang Na Li Na Li Qianfeng Xia Qianfeng Xia The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box Frontiers in Microbiology COVID-19 genome gut microbiota infectious diseases SARS-CoV-2 |
| title | The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box |
| title_full | The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box |
| title_fullStr | The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box |
| title_full_unstemmed | The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box |
| title_short | The triangle relationship between human genome, gut microbiome, and COVID-19: opening of a Pandora’s box |
| title_sort | triangle relationship between human genome gut microbiome and covid 19 opening of a pandora s box |
| topic | COVID-19 genome gut microbiota infectious diseases SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1190939/full |
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