Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

Abstract Background According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk between microglia P2X4Rs and neurons of the trigeminal nucleus caudalis (TNC...

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Bibliographic Details
Main Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zhou
Format: Article
Language:English
Published: BMC 2020-01-01
Series:The Journal of Headache and Pain
Subjects:
Chronic migraine
Central sensitization
Microglia
P2X4R
BDNF
Online Access:https://doi.org/10.1186/s10194-019-1070-4

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