A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values
Purpose: Despite refinements in surgical techniques for liver resection, evaluation of hepatic reserve disparity remains one of the most common problems in liver surgery, especially for hepatic malignancies such as hepatocellular carcinoma (HCC). Portal venous pressure (PVP) is regarded one of the i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2018.1476631 |
| _version_ | 1827817445302206464 |
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| author | Masaaki Hidaka Susumu Eguchi Takanobu Hara Akihiko Soyama Satomi Okada Takashi Hamada Shinichiro Ono Tomohiko Adachi Kengo Kanetaka Mitsuhisa Takatsuki |
| author_facet | Masaaki Hidaka Susumu Eguchi Takanobu Hara Akihiko Soyama Satomi Okada Takashi Hamada Shinichiro Ono Tomohiko Adachi Kengo Kanetaka Mitsuhisa Takatsuki |
| author_sort | Masaaki Hidaka |
| collection | DOAJ |
| description | Purpose: Despite refinements in surgical techniques for liver resection, evaluation of hepatic reserve disparity remains one of the most common problems in liver surgery, especially for hepatic malignancies such as hepatocellular carcinoma (HCC). Portal venous pressure (PVP) is regarded one of the important factors in selecting treatment strategy, although its measurement can be invasive and complex. Methods: To establish a formula for calculating PVP preoperatively, intraoperative directly measured PVP was used in 177 patients with preoperative factors and liver function tests such as age, sex, virus status, platelet count, prothrombin time, albumin, total bilirubin, alanine aminotransferase (ALT), Child–Pugh grade, liver damage defined by the Liver Cancer Study Group of Japan, indocyanine green retention rate at 15 min (ICG-R15), and the aspartate transaminase (AST)-platelet ratio index (APRI). Results: Although 90% of the patients were classified as Child-Pugh A, median direct PVP was 16.5 cm H2O (5.5–37.0) and the percentage of PVP greater than 20 cm H2O was 27.1%, reflecting portal hypertension due to liver damage. After multiple regression analysis, the formula PVP (cmH2O) = EXP[2.606 + 0.01 × (ICG-R15) + 0.015 × APRI] was established from the measured data. Conclusion: Considering its simplicity of use, we have adopted this formula for predicting PVP in determining treatment strategy for HCC and other hepatic malignancies. |
| first_indexed | 2024-03-12T00:34:21Z |
| format | Article |
| id | doaj.art-a695eb8c54c949e1aa2ed799f9c3c05d |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:34:21Z |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-a695eb8c54c949e1aa2ed799f9c3c05d2023-09-15T10:07:28ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532020-02-0133211812210.1080/08941939.2018.14766311476631A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured ValuesMasaaki Hidaka0Susumu Eguchi1Takanobu Hara2Akihiko Soyama3Satomi Okada4Takashi Hamada5Shinichiro Ono6Tomohiko Adachi7Kengo Kanetaka8Mitsuhisa Takatsuki9Nagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesNagasaki University Graduate School of Biomedical SciencesPurpose: Despite refinements in surgical techniques for liver resection, evaluation of hepatic reserve disparity remains one of the most common problems in liver surgery, especially for hepatic malignancies such as hepatocellular carcinoma (HCC). Portal venous pressure (PVP) is regarded one of the important factors in selecting treatment strategy, although its measurement can be invasive and complex. Methods: To establish a formula for calculating PVP preoperatively, intraoperative directly measured PVP was used in 177 patients with preoperative factors and liver function tests such as age, sex, virus status, platelet count, prothrombin time, albumin, total bilirubin, alanine aminotransferase (ALT), Child–Pugh grade, liver damage defined by the Liver Cancer Study Group of Japan, indocyanine green retention rate at 15 min (ICG-R15), and the aspartate transaminase (AST)-platelet ratio index (APRI). Results: Although 90% of the patients were classified as Child-Pugh A, median direct PVP was 16.5 cm H2O (5.5–37.0) and the percentage of PVP greater than 20 cm H2O was 27.1%, reflecting portal hypertension due to liver damage. After multiple regression analysis, the formula PVP (cmH2O) = EXP[2.606 + 0.01 × (ICG-R15) + 0.015 × APRI] was established from the measured data. Conclusion: Considering its simplicity of use, we have adopted this formula for predicting PVP in determining treatment strategy for HCC and other hepatic malignancies.http://dx.doi.org/10.1080/08941939.2018.1476631portal venous pressureformulahepatocellular carcinomaresectionprediction |
| spellingShingle | Masaaki Hidaka Susumu Eguchi Takanobu Hara Akihiko Soyama Satomi Okada Takashi Hamada Shinichiro Ono Tomohiko Adachi Kengo Kanetaka Mitsuhisa Takatsuki A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values Journal of Investigative Surgery portal venous pressure formula hepatocellular carcinoma resection prediction |
| title | A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values |
| title_full | A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values |
| title_fullStr | A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values |
| title_full_unstemmed | A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values |
| title_short | A Predictive Formula for Portal Venous Pressure Prior to Liver Resection Using Directly Measured Values |
| title_sort | predictive formula for portal venous pressure prior to liver resection using directly measured values |
| topic | portal venous pressure formula hepatocellular carcinoma resection prediction |
| url | http://dx.doi.org/10.1080/08941939.2018.1476631 |
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