Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1) have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy. Despite the inherent advantages of small-molecule inhibitors over antibodies, the discovery of small-molecule inhibitors has fallen behind...

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Podrobná bibliografie
Hlavní autoři: Chengliang Sun, Yao Cheng, Xiaojia Liu, Gefei Wang, Wenjian Min, Xiao Wang, Kai Yuan, Yi Hou, Jiaxing Li, Haolin Zhang, Haojie Dong, Liping Wang, Chenguang Lou, Yanze Sun, Xinmiao Yu, Hongbin Deng, Yibei Xiao, Peng Yang
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2022-12-01
Edice:Acta Pharmaceutica Sinica B
Témata:
PD-1/PD-L1
Small-molecule inhibitor
Immunotherapy
Co-crystal structure
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211383522001770

Internet

http://www.sciencedirect.com/science/article/pii/S2211383522001770

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