Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1) have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy. Despite the inherent advantages of small-molecule inhibitors over antibodies, the discovery of small-molecule inhibitors has fallen behind...

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Príomhchruthaitheoirí: Chengliang Sun, Yao Cheng, Xiaojia Liu, Gefei Wang, Wenjian Min, Xiao Wang, Kai Yuan, Yi Hou, Jiaxing Li, Haolin Zhang, Haojie Dong, Liping Wang, Chenguang Lou, Yanze Sun, Xinmiao Yu, Hongbin Deng, Yibei Xiao, Peng Yang
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2022-12-01
Sraith:Acta Pharmaceutica Sinica B
Ábhair:
PD-1/PD-L1
Small-molecule inhibitor
Immunotherapy
Co-crystal structure
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211383522001770

Ar líne

http://www.sciencedirect.com/science/article/pii/S2211383522001770

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