Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1) have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy. Despite the inherent advantages of small-molecule inhibitors over antibodies, the discovery of small-molecule inhibitors has fallen behind...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Chengliang Sun, Yao Cheng, Xiaojia Liu, Gefei Wang, Wenjian Min, Xiao Wang, Kai Yuan, Yi Hou, Jiaxing Li, Haolin Zhang, Haojie Dong, Liping Wang, Chenguang Lou, Yanze Sun, Xinmiao Yu, Hongbin Deng, Yibei Xiao, Peng Yang
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2022-12-01
Цуврал:Acta Pharmaceutica Sinica B
Нөхцлүүд:
PD-1/PD-L1
Small-molecule inhibitor
Immunotherapy
Co-crystal structure
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S2211383522001770

Интернэт

http://www.sciencedirect.com/science/article/pii/S2211383522001770

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