The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent informat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11533 |
| _version_ | 1797512512019628032 |
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| author | Dominika Mech Antonina Kurowska Nazar Trotsko |
| author_facet | Dominika Mech Antonina Kurowska Nazar Trotsko |
| author_sort | Dominika Mech |
| collection | DOAJ |
| description | Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones. |
| first_indexed | 2024-03-10T06:01:53Z |
| format | Article |
| id | doaj.art-a6995943bf8f46cea6b9557cba82c1ca |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:53Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a6995943bf8f46cea6b9557cba82c1ca2023-11-22T20:53:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211153310.3390/ijms222111533The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent StudiesDominika Mech0Antonina Kurowska1Nazar Trotsko2Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, PolandThiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.https://www.mdpi.com/1422-0067/22/21/11533thiazolidine-4-onesantioxidant activityanticancer activityanti-inflammatory activityantidiabetic activityantiparasitic activity |
| spellingShingle | Dominika Mech Antonina Kurowska Nazar Trotsko The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies International Journal of Molecular Sciences thiazolidine-4-ones antioxidant activity anticancer activity anti-inflammatory activity antidiabetic activity antiparasitic activity |
| title | The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies |
| title_full | The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies |
| title_fullStr | The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies |
| title_full_unstemmed | The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies |
| title_short | The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies |
| title_sort | bioactivity of thiazolidin 4 ones a short review of the most recent studies |
| topic | thiazolidine-4-ones antioxidant activity anticancer activity anti-inflammatory activity antidiabetic activity antiparasitic activity |
| url | https://www.mdpi.com/1422-0067/22/21/11533 |
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