Bile acid transporters
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation. In the liv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-12-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520306581 |
| _version_ | 1819077244636626944 |
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| author | Paul A. Dawson Tian Lan Anuradha Rao |
| author_facet | Paul A. Dawson Tian Lan Anuradha Rao |
| author_sort | Paul A. Dawson |
| collection | DOAJ |
| description | In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation. In the liver, bile acids are efficiently transported across the sinusoidal membrane by the Na+ taurocholate cotransporting polypeptide with assistance by members of the organic anion transporting polypeptide family. The bile acids are then secreted in an ATP-dependent fashion across the canalicular membrane by the bile salt export pump. Following their movement with bile into the lumen of the small intestine, bile acids are almost quantitatively reclaimed in the ileum by the apical sodium-dependent bile acid transporter. The bile acids are shuttled across the enterocyte to the basolateral membrane and effluxed into the portal circulation by the recently indentified heteromeric organic solute transporter, OSTα-OSTβ. In addition to the hepatocyte and enterocyte, subgroups of these bile acid transporters are expressed by the biliary, renal, and colonic epithelium where they contribute to maintaining bile acid homeostasis and play important cytoprotective roles. This article will review our current understanding of the physiological role and regulation of these important carriers. |
| first_indexed | 2024-12-21T18:54:07Z |
| format | Article |
| id | doaj.art-a69a368787ad4162b3b46888328397a4 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-21T18:54:07Z |
| publishDate | 2009-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-a69a368787ad4162b3b46888328397a42022-12-21T18:53:40ZengElsevierJournal of Lipid Research0022-22752009-12-01501223402357Bile acid transportersPaul A. Dawson0Tian Lan1Anuradha Rao2To whom correspondence should be addressed; Department of Internal Medicine and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157Department of Internal Medicine and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157Department of Internal Medicine and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation. In the liver, bile acids are efficiently transported across the sinusoidal membrane by the Na+ taurocholate cotransporting polypeptide with assistance by members of the organic anion transporting polypeptide family. The bile acids are then secreted in an ATP-dependent fashion across the canalicular membrane by the bile salt export pump. Following their movement with bile into the lumen of the small intestine, bile acids are almost quantitatively reclaimed in the ileum by the apical sodium-dependent bile acid transporter. The bile acids are shuttled across the enterocyte to the basolateral membrane and effluxed into the portal circulation by the recently indentified heteromeric organic solute transporter, OSTα-OSTβ. In addition to the hepatocyte and enterocyte, subgroups of these bile acid transporters are expressed by the biliary, renal, and colonic epithelium where they contribute to maintaining bile acid homeostasis and play important cytoprotective roles. This article will review our current understanding of the physiological role and regulation of these important carriers.http://www.sciencedirect.com/science/article/pii/S0022227520306581bile acidscholesterolnuclear receptorscholestasisenterohepatic circulation |
| spellingShingle | Paul A. Dawson Tian Lan Anuradha Rao Bile acid transporters Journal of Lipid Research bile acids cholesterol nuclear receptors cholestasis enterohepatic circulation |
| title | Bile acid transporters |
| title_full | Bile acid transporters |
| title_fullStr | Bile acid transporters |
| title_full_unstemmed | Bile acid transporters |
| title_short | Bile acid transporters |
| title_sort | bile acid transporters |
| topic | bile acids cholesterol nuclear receptors cholestasis enterohepatic circulation |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520306581 |
| work_keys_str_mv | AT pauladawson bileacidtransporters AT tianlan bileacidtransporters AT anuradharao bileacidtransporters |