Synthesis of Isotope labeled Trichlorfon-methoxyl-D6 and Dichlorophos-methoxyl-D6
The efficient synthesis of two labeled standards trichlorfon-methoxyl-D6 and dichlorophos- methoxyl-D6 with CD3OD as the precursor were presented. Esterification of phosphorus trichloride with CD3OD provided dimethyl phosphate-methoxyl-D6, which was used to condense with trichloroaldehyde to give tr...
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| Format: | Article |
| Language: | zho |
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Editorial Board of Journal of Isotopes
2014-02-01
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| Series: | Journal of Isotopes |
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| Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0008 |
| Summary: | The efficient synthesis of two labeled standards trichlorfon-methoxyl-D6 and dichlorophos- methoxyl-D6 with CD3OD as the precursor were presented. Esterification of phosphorus trichloride with CD3OD provided dimethyl phosphate-methoxyl-D6, which was used to condense with trichloroaldehyde to give trichlorfon-methoxyl-D6. Ttrichlorfon-methoxyl-D6 was further converted to dichlorophos-methoxyl-D6 by alkaline hydrolysis and rearrangement. The yields of trichlorfon-methoxyl-D6 and Dichlorophos-methoxyl-D6 were 57.7 % and 47.3% respectively based on CD3OD consumed. Both products were characterized by HPLC, MS, and NMR to be target compounds. Their chemical purities and isotopic enrichment were higher than 98.0%. The above compounds could be used as internal standards in the food safety field. |
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| ISSN: | 1000-7512 1000-7512 |