Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo
For developing an effective interventional approach and treatment modality for PM2.5, the effects of omega-3 fatty acids on alleviating inflammation and attenuating lung injury induced by inhalation exposure of PM2.5 were assessed in murine models. We found that daily oral administration of the acti...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/10/5323 |
| _version_ | 1797499311476441088 |
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| author | Juan Li Meiru Mao Jiacheng Li Ziteng Chen Ying Ji Jianglong Kong Zhijie Wang Jiaxin Zhang Yujiao Wang Wei Liang Haojun Liang Linwen Lv Qiuyang Liu Ruyu Yan Hui Yuan Kui Chen Yanan Chang Guogang Chen Gengmei Xing |
| author_facet | Juan Li Meiru Mao Jiacheng Li Ziteng Chen Ying Ji Jianglong Kong Zhijie Wang Jiaxin Zhang Yujiao Wang Wei Liang Haojun Liang Linwen Lv Qiuyang Liu Ruyu Yan Hui Yuan Kui Chen Yanan Chang Guogang Chen Gengmei Xing |
| author_sort | Juan Li |
| collection | DOAJ |
| description | For developing an effective interventional approach and treatment modality for PM2.5, the effects of omega-3 fatty acids on alleviating inflammation and attenuating lung injury induced by inhalation exposure of PM2.5 were assessed in murine models. We found that daily oral administration of the active components of omega-3 fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) effectively alleviated lung parenchymal lesions, restored normal inflammatory cytokine levels and oxidative stress levels in treating mice exposed to PM2.5 (20 mg/kg) every 3 days for 5 times over a 14-day period. Especially, CT images and the pathological analysis suggested protective effects of DHA and EPA on lung injury. The key molecular mechanism is that DHA and EPA can inhibit the entry and deposition of PM2.5, and block the PM2.5-mediated cytotoxicity, oxidative stress, and inflammation. |
| first_indexed | 2024-03-10T03:45:36Z |
| format | Article |
| id | doaj.art-a69b8a5f5f074fa2b9cadf335eca8618 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:45:36Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a69b8a5f5f074fa2b9cadf335eca86182023-11-23T11:20:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310532310.3390/ijms23105323Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In VivoJuan Li0Meiru Mao1Jiacheng Li2Ziteng Chen3Ying Ji4Jianglong Kong5Zhijie Wang6Jiaxin Zhang7Yujiao Wang8Wei Liang9Haojun Liang10Linwen Lv11Qiuyang Liu12Ruyu Yan13Hui Yuan14Kui Chen15Yanan Chang16Guogang Chen17Gengmei Xing18CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaInstitute of Textiles and Clothing, Hong Kong Polytechnic University, Hunghom, Kowloon, Hong KongCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaCollege of Food Science, Shihezi University, Shihezi 832000, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, ChinaFor developing an effective interventional approach and treatment modality for PM2.5, the effects of omega-3 fatty acids on alleviating inflammation and attenuating lung injury induced by inhalation exposure of PM2.5 were assessed in murine models. We found that daily oral administration of the active components of omega-3 fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) effectively alleviated lung parenchymal lesions, restored normal inflammatory cytokine levels and oxidative stress levels in treating mice exposed to PM2.5 (20 mg/kg) every 3 days for 5 times over a 14-day period. Especially, CT images and the pathological analysis suggested protective effects of DHA and EPA on lung injury. The key molecular mechanism is that DHA and EPA can inhibit the entry and deposition of PM2.5, and block the PM2.5-mediated cytotoxicity, oxidative stress, and inflammation.https://www.mdpi.com/1422-0067/23/10/5323PM2.5lung injuryomega-3 fatty acidsdocosahexaenoic acideicosapentaenoic acid |
| spellingShingle | Juan Li Meiru Mao Jiacheng Li Ziteng Chen Ying Ji Jianglong Kong Zhijie Wang Jiaxin Zhang Yujiao Wang Wei Liang Haojun Liang Linwen Lv Qiuyang Liu Ruyu Yan Hui Yuan Kui Chen Yanan Chang Guogang Chen Gengmei Xing Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo International Journal of Molecular Sciences PM2.5 lung injury omega-3 fatty acids docosahexaenoic acid eicosapentaenoic acid |
| title | Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo |
| title_full | Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo |
| title_fullStr | Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo |
| title_full_unstemmed | Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo |
| title_short | Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo |
| title_sort | oral administration of omega 3 fatty acids attenuates lung injury caused by pm2 5 respiratory inhalation simply and feasibly in vivo |
| topic | PM2.5 lung injury omega-3 fatty acids docosahexaenoic acid eicosapentaenoic acid |
| url | https://www.mdpi.com/1422-0067/23/10/5323 |
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