Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Abstract Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made to decipher the role of EpCAM in cancers. Great advances have been achieved in eluc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-022-00352-4 |
| _version_ | 1817970311119765504 |
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| author | Yiyang Liu Yufei Wang Sheng Sun Zeyu Chen Shuai Xiang Zeyang Ding Zhao Huang Bixiang Zhang |
| author_facet | Yiyang Liu Yufei Wang Sheng Sun Zeyu Chen Shuai Xiang Zeyang Ding Zhao Huang Bixiang Zhang |
| author_sort | Yiyang Liu |
| collection | DOAJ |
| description | Abstract Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made to decipher the role of EpCAM in cancers. Great advances have been achieved in elucidating its structure, molecular functions, pathophysiological mechanisms, and clinical applications. Beyond its well-recognized role as a biomarker of cancer stem cells (CSCs) or circulating tumor cells (CTCs), EpCAM exhibits novel and promising value in targeted therapy. At the same time, the roles of EpCAM in cancer progression are found to be highly context-dependent and even contradictory in some cases. The versatile functional modules of EpCAM and its communication with other signaling pathways complicate the study of this molecule. In this review, we start from the structure of EpCAM and focus on communication with other signaling pathways. The impacts on the biology of cancers and the up-to-date clinical applications of EpCAM are also introduced and summarized, aiming to shed light on the translational prospects of EpCAM. |
| first_indexed | 2024-04-13T20:32:37Z |
| format | Article |
| id | doaj.art-a69b8e4d0e8144a8bd73a8482ba291f8 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-04-13T20:32:37Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-a69b8e4d0e8144a8bd73a8482ba291f82022-12-22T02:31:08ZengBMCExperimental Hematology & Oncology2162-36192022-11-0111111910.1186/s40164-022-00352-4Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedsideYiyang Liu0Yufei Wang1Sheng Sun2Zeyu Chen3Shuai Xiang4Zeyang Ding5Zhao Huang6Bixiang Zhang7Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made to decipher the role of EpCAM in cancers. Great advances have been achieved in elucidating its structure, molecular functions, pathophysiological mechanisms, and clinical applications. Beyond its well-recognized role as a biomarker of cancer stem cells (CSCs) or circulating tumor cells (CTCs), EpCAM exhibits novel and promising value in targeted therapy. At the same time, the roles of EpCAM in cancer progression are found to be highly context-dependent and even contradictory in some cases. The versatile functional modules of EpCAM and its communication with other signaling pathways complicate the study of this molecule. In this review, we start from the structure of EpCAM and focus on communication with other signaling pathways. The impacts on the biology of cancers and the up-to-date clinical applications of EpCAM are also introduced and summarized, aiming to shed light on the translational prospects of EpCAM.https://doi.org/10.1186/s40164-022-00352-4EpCAMCancerCell signalingExtracellular vesiclesImmuneTherapy |
| spellingShingle | Yiyang Liu Yufei Wang Sheng Sun Zeyu Chen Shuai Xiang Zeyang Ding Zhao Huang Bixiang Zhang Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside Experimental Hematology & Oncology EpCAM Cancer Cell signaling Extracellular vesicles Immune Therapy |
| title | Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside |
| title_full | Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside |
| title_fullStr | Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside |
| title_full_unstemmed | Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside |
| title_short | Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside |
| title_sort | understanding the versatile roles and applications of epcam in cancers from bench to bedside |
| topic | EpCAM Cancer Cell signaling Extracellular vesicles Immune Therapy |
| url | https://doi.org/10.1186/s40164-022-00352-4 |
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