Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics
N6-methyladenine (m6A) is one of the most common RNA epigenetic modifications in all higher eukaryotes. Increasing evidence demonstrated that m6A-related proteins, acted as oncogenes or tumor suppressors, are abnormally expressed in the cell lines and tissues of non-small cell lung cancer (NSCLC). I...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.972655/full |
| _version_ | 1817991940826726400 |
|---|---|
| author | Fen-Sheng Qiu Jia-Qi He Yu-Sen Zhong Mei-Ying Guo Chen-Huan Yu Chen-Huan Yu Chen-Huan Yu |
| author_facet | Fen-Sheng Qiu Jia-Qi He Yu-Sen Zhong Mei-Ying Guo Chen-Huan Yu Chen-Huan Yu Chen-Huan Yu |
| author_sort | Fen-Sheng Qiu |
| collection | DOAJ |
| description | N6-methyladenine (m6A) is one of the most common RNA epigenetic modifications in all higher eukaryotes. Increasing evidence demonstrated that m6A-related proteins, acted as oncogenes or tumor suppressors, are abnormally expressed in the cell lines and tissues of non-small cell lung cancer (NSCLC). In addition, lung as the special immune organ contacts with the outer environments and thereby inevitably suffers from different types of microbial pathogen attack. Those microbial pathogens affect the development, progression, and clinical outcomes of NSCLC via altering host m6A modification to disrupt pulmonary immune homeostasis and increase the susceptibility; conversely, host cells modulate m6A modification to repress bacterial colonization. Therefore, m6A harbors the potential to be the novel biomarkers and targets for predicting poor prognosis and chemotherapy sensitivity of patients with lung cancer. In this paper, we provided an overview of the biological properties of m6A-modifying enzymes, and the mechanistic links among lung microbiota, m6A modification and NSCLC. Although the flood of novel m6A-related inhibitors represents many dramatic improvements in NSCLC therapy, their efficacy and toxicity in NSCLC are explored to address these pivotal gaps in the field. |
| first_indexed | 2024-04-14T01:19:52Z |
| format | Article |
| id | doaj.art-a69d56ff09b7438e8b44160849164381 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-14T01:19:52Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-a69d56ff09b7438e8b441608491643812022-12-22T02:20:42ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-09-011210.3389/fcimb.2022.972655972655Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeuticsFen-Sheng Qiu0Jia-Qi He1Yu-Sen Zhong2Mei-Ying Guo3Chen-Huan Yu4Chen-Huan Yu5Chen-Huan Yu6Key Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences (Hangzhou Medical College), Hangzhou, ChinaPharmaceutical Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences (Hangzhou Medical College), Hangzhou, ChinaKey Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences (Hangzhou Medical College), Hangzhou, ChinaKey Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences (Hangzhou Medical College), Hangzhou, ChinaCancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, ChinaInstitute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, ChinaN6-methyladenine (m6A) is one of the most common RNA epigenetic modifications in all higher eukaryotes. Increasing evidence demonstrated that m6A-related proteins, acted as oncogenes or tumor suppressors, are abnormally expressed in the cell lines and tissues of non-small cell lung cancer (NSCLC). In addition, lung as the special immune organ contacts with the outer environments and thereby inevitably suffers from different types of microbial pathogen attack. Those microbial pathogens affect the development, progression, and clinical outcomes of NSCLC via altering host m6A modification to disrupt pulmonary immune homeostasis and increase the susceptibility; conversely, host cells modulate m6A modification to repress bacterial colonization. Therefore, m6A harbors the potential to be the novel biomarkers and targets for predicting poor prognosis and chemotherapy sensitivity of patients with lung cancer. In this paper, we provided an overview of the biological properties of m6A-modifying enzymes, and the mechanistic links among lung microbiota, m6A modification and NSCLC. Although the flood of novel m6A-related inhibitors represents many dramatic improvements in NSCLC therapy, their efficacy and toxicity in NSCLC are explored to address these pivotal gaps in the field.https://www.frontiersin.org/articles/10.3389/fcimb.2022.972655/fullepigeneticsbiomarkerMETTL3FTOinhibitorm6A |
| spellingShingle | Fen-Sheng Qiu Jia-Qi He Yu-Sen Zhong Mei-Ying Guo Chen-Huan Yu Chen-Huan Yu Chen-Huan Yu Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics Frontiers in Cellular and Infection Microbiology epigenetics biomarker METTL3 FTO inhibitor m6A |
| title | Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics |
| title_full | Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics |
| title_fullStr | Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics |
| title_full_unstemmed | Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics |
| title_short | Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics |
| title_sort | implications of m6a methylation and microbiota interaction in non small cell lung cancer from basics to therapeutics |
| topic | epigenetics biomarker METTL3 FTO inhibitor m6A |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.972655/full |
| work_keys_str_mv | AT fenshengqiu implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT jiaqihe implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT yusenzhong implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT meiyingguo implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT chenhuanyu implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT chenhuanyu implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics AT chenhuanyu implicationsofm6amethylationandmicrobiotainteractioninnonsmallcelllungcancerfrombasicstotherapeutics |