Interrogation of human microglial phagocytosis by CRISPR genome editing

BackgroundMicroglia are an integral part of central nervous system, but our understanding of microglial biology is limited due to the challenges in obtaining and culturing primary human microglia. HMC3 is an important cell line for studying human microglia because it is readily accessible and straig...

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Bibliographic Details
Main Authors: Jason Cheng-Yu Chang, Cheng-You Wang, Steven Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1169725/full