Application of HPLC-QQQ-MS/MS and New RP-HPLC-DAD System Utilizing the Chaotropic Effect for Determination of Nicotine and Its Major Metabolites Cotinine, and <i>trans</i>-3′-Hydroxycotinine in Human Plasma Samples

Application of HPLC-QQQ-MS/MS and New RP-HPLC-DAD System Utilizing the Chaotropic Effect for Determination of Nicotine and Its Major Metabolites Cotinine, and <i>trans</i>-3′-Hydroxycotinine in Human Plasma Samples

The routine techniques currently applied for the determination of nicotine and its major metabolites, cotinine, and <i>trans</i>-3′-hydroxycotinine, in biological fluids, include spectrophotometric, immunoassays, and chromatographic techniques. The aim of this study was to develop, and c...

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Bibliographic Details
Main Authors: Jacek Baj, Wojciech Flieger, Dominika Przygodzka, Grzegorz Buszewicz, Grzegorz Teresiński, Magdalena Pizoń, Ryszard Maciejewski, Jolanta Flieger
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
nicotine
cotinine
<i>trans</i>-3′-hydroxycotinine
RP-HPLC-DAD
HPLC-QQQ-MS/MS chaotropic effect
Online Access:https://www.mdpi.com/1420-3049/27/3/682

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