Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population
Diabetes is a chronic group of metabolic disorders those generally present with hyperglycemia hence insulin synthesis defects due to multifactorial causes in beta cells in the Langerhans islets of the pancreas. In the development of diabetes, genetic predisposition is as important as environmental f...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-06-01
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| Series: | Türk Biyokimya Dergisi |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tjb-2021-0235 |
| _version_ | 1811320081893818368 |
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| author | Oğuz Osman Gheybi Arezoo Doğan Zeliha Akbaş Feray Zeybek Ümit Ergen Arzu |
| author_facet | Oğuz Osman Gheybi Arezoo Doğan Zeliha Akbaş Feray Zeybek Ümit Ergen Arzu |
| author_sort | Oğuz Osman |
| collection | DOAJ |
| description | Diabetes is a chronic group of metabolic disorders those generally present with hyperglycemia hence insulin synthesis defects due to multifactorial causes in beta cells in the Langerhans islets of the pancreas. In the development of diabetes, genetic predisposition is as important as environmental factors. As a result of polymorphism studies in diabetic patients, many genes were associated with the development of diabetes. In our study, we aimed to represent the relationship between diabetes and certain variants of the ghrelin (GHRL), fat mass and obesity-associated protein (FTO) and peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α) genes which are generally associated with diabetes and obesity. |
| first_indexed | 2024-04-13T12:54:03Z |
| format | Article |
| id | doaj.art-a69f1eb81cb644968262638b294016c7 |
| institution | Directory Open Access Journal |
| issn | 1303-829X |
| language | English |
| last_indexed | 2024-04-13T12:54:03Z |
| publishDate | 2022-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj.art-a69f1eb81cb644968262638b294016c72022-12-22T02:46:07ZengDe GruyterTürk Biyokimya Dergisi1303-829X2022-06-0147556457010.1515/tjb-2021-0235Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish populationOğuz Osman0Gheybi Arezoo1Doğan Zeliha2Akbaş Feray3Zeybek Ümit4Ergen Arzu5Department of Core Clinical Biochemistry, American Hospital, Istanbul, TurkeyAziz Sancar Institute of Experimental Medicine, Molecular Medicine, Istanbul University, Istanbul, TurkeyAziz Sancar Institute of Experimental Medicine, Molecular Medicine, Istanbul University, Istanbul, TurkeyDepartment of Internal Medicine, Istanbul Education and Research Hospital, Istanbul, TurkeyAziz Sancar Institute of Experimental Medicine, Molecular Medicine, Istanbul University, Istanbul, TurkeyAziz Sancar Institute of Experimental Medicine, Molecular Medicine, Istanbul University, Istanbul, TurkeyDiabetes is a chronic group of metabolic disorders those generally present with hyperglycemia hence insulin synthesis defects due to multifactorial causes in beta cells in the Langerhans islets of the pancreas. In the development of diabetes, genetic predisposition is as important as environmental factors. As a result of polymorphism studies in diabetic patients, many genes were associated with the development of diabetes. In our study, we aimed to represent the relationship between diabetes and certain variants of the ghrelin (GHRL), fat mass and obesity-associated protein (FTO) and peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α) genes which are generally associated with diabetes and obesity.https://doi.org/10.1515/tjb-2021-0235genetic polymorphismghrelinsingle nucleotide polymorphismtype 2 diabetes mellitus |
| spellingShingle | Oğuz Osman Gheybi Arezoo Doğan Zeliha Akbaş Feray Zeybek Ümit Ergen Arzu Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population Türk Biyokimya Dergisi genetic polymorphism ghrelin single nucleotide polymorphism type 2 diabetes mellitus |
| title | Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population |
| title_full | Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population |
| title_fullStr | Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population |
| title_full_unstemmed | Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population |
| title_short | Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population |
| title_sort | investigation of ghrl rs4684677 fto rs8044769 and pgc1α rs8192678 polymorphisms in type 2 diabetic turkish population |
| topic | genetic polymorphism ghrelin single nucleotide polymorphism type 2 diabetes mellitus |
| url | https://doi.org/10.1515/tjb-2021-0235 |
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