Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease
Abstract Balance dysfunction is a disabling symptom in people with Parkinson’s disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cogniti...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00269-5 |
| _version_ | 1827776524366905344 |
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| author | Malin Freidle Hanna Johansson Urban Ekman Alexander V. Lebedev Ellika Schalling William H. Thompson Per Svenningsson Martin Lövdén Alonso Abney Franziska Albrecht Hanna Steurer Breiffni Leavy Staffan Holmin Maria Hagströmer Erika Franzén |
| author_facet | Malin Freidle Hanna Johansson Urban Ekman Alexander V. Lebedev Ellika Schalling William H. Thompson Per Svenningsson Martin Lövdén Alonso Abney Franziska Albrecht Hanna Steurer Breiffni Leavy Staffan Holmin Maria Hagströmer Erika Franzén |
| author_sort | Malin Freidle |
| collection | DOAJ |
| description | Abstract Balance dysfunction is a disabling symptom in people with Parkinson’s disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind randomised controlled trial (RCT) where 95 participants with PD were randomised to either HiBalance (n = 48) or a control group (n = 47). We found no significant group by time effect on balance performance (b = 0.4 95% CI [−1, 1.9], p = 0.57) or on our secondary outcomes, including the measures of task-evoked brain activity. The findings of this well-powered, double-blind RCT contrast previous studies of the HiBalance programme but are congruent with other double-blind RCTs of physical exercise in PD. The divergent results raise important questions on how to optimise physical exercise interventions for people with PD. Preregistration clinicaltrials.gov: NCT03213873. |
| first_indexed | 2024-03-11T14:06:24Z |
| format | Article |
| id | doaj.art-a69f4f660261428a961d4187b5cb24fc |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T14:06:24Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-a69f4f660261428a961d4187b5cb24fc2023-11-02T02:12:14ZengNature Portfolionpj Parkinson's Disease2373-80572022-01-018111010.1038/s41531-021-00269-5Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s diseaseMalin Freidle0Hanna Johansson1Urban Ekman2Alexander V. Lebedev3Ellika Schalling4William H. Thompson5Per Svenningsson6Martin Lövdén7Alonso Abney8Franziska Albrecht9Hanna Steurer10Breiffni Leavy11Staffan Holmin12Maria Hagströmer13Erika Franzén14Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska InstitutetDepartment of Clinical Neuroscience, Division of Neuro, Karolinska InstitutetDepartment of Public Health and Caring Sciences, Uppsala UniversityDepartment of Clinical Neuroscience, Division of Neuro, Karolinska InstitutetDepartment of Clinical Neuroscience, Division of Neuro, Karolinska InstitutetDepartment of Psychology, University of GothenburgDepartment of Clinical Neuroscience, Division of Neuro, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetDepartment of Clinical Science, Intervention and Technology—CLINTEC, Division of Speech and Language Pathology, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetDepartment of Clinical Neuroscience, Division of Neuro, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska InstitutetAbstract Balance dysfunction is a disabling symptom in people with Parkinson’s disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind randomised controlled trial (RCT) where 95 participants with PD were randomised to either HiBalance (n = 48) or a control group (n = 47). We found no significant group by time effect on balance performance (b = 0.4 95% CI [−1, 1.9], p = 0.57) or on our secondary outcomes, including the measures of task-evoked brain activity. The findings of this well-powered, double-blind RCT contrast previous studies of the HiBalance programme but are congruent with other double-blind RCTs of physical exercise in PD. The divergent results raise important questions on how to optimise physical exercise interventions for people with PD. Preregistration clinicaltrials.gov: NCT03213873.https://doi.org/10.1038/s41531-021-00269-5 |
| spellingShingle | Malin Freidle Hanna Johansson Urban Ekman Alexander V. Lebedev Ellika Schalling William H. Thompson Per Svenningsson Martin Lövdén Alonso Abney Franziska Albrecht Hanna Steurer Breiffni Leavy Staffan Holmin Maria Hagströmer Erika Franzén Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease npj Parkinson's Disease |
| title | Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease |
| title_full | Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease |
| title_fullStr | Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease |
| title_full_unstemmed | Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease |
| title_short | Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease |
| title_sort | behavioural and neuroplastic effects of a double blind randomised controlled balance exercise trial in people with parkinson s disease |
| url | https://doi.org/10.1038/s41531-021-00269-5 |
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