Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair
Changes in pharyngeal and upper-esophageal-sphincter (UES) motor dynamics contribute to swallowing dysfunction. Children with type 1 laryngeal clefts can present with swallowing dysfunction and associated symptoms which may persist even after the initial endoscopic intervention. This study sought to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/1/15 |
| _version_ | 1797344567610048512 |
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| author | Corey Baker Casey Silvernale Christopher Hartnick Claire Zar-Kessler |
| author_facet | Corey Baker Casey Silvernale Christopher Hartnick Claire Zar-Kessler |
| author_sort | Corey Baker |
| collection | DOAJ |
| description | Changes in pharyngeal and upper-esophageal-sphincter (UES) motor dynamics contribute to swallowing dysfunction. Children with type 1 laryngeal clefts can present with swallowing dysfunction and associated symptoms which may persist even after the initial endoscopic intervention. This study sought to characterize pharyngeal and esophageal motor function in children with type 1 laryngeal clefts who had persistent presenting symptoms after their initial therapeutic intervention. We retrospectively analyzed high-resolution esophageal manometry studies of children ≤ 18 years old with type 1 laryngeal clefts who had an esophageal manometry study performed for persistent symptoms after an initial repair. A total of 16 children were found to have significantly increased UES resting pressure, UES pre- and post-swallow maximum pressures, and duration of UES contraction during swallows in comparison to nine age-matched controls of children without pharyngeal anatomical abnormalities. There was no difference between UES residual pressures or pharyngeal dynamics between the two groups. UES resting and residual pressures did not correlate with VFFS in penetration and aspiration scores of children with type 1 laryngeal clefts status post repair. Our study is the first to identify specific changes in UES motor function in patients with type 1 laryngeal cleft post initial repair. |
| first_indexed | 2024-03-08T11:04:35Z |
| format | Article |
| id | doaj.art-a6a022be581f465aab940b5ab88d4c1f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-08T11:04:35Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a6a022be581f465aab940b5ab88d4c1f2024-01-26T15:17:41ZengMDPI AGBiomolecules2218-273X2023-12-011411510.3390/biom14010015Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft RepairCorey Baker0Casey Silvernale1Christopher Hartnick2Claire Zar-Kessler3Pediatric Gastroenterology, Hepatology and Nutrition, Connecticut Children, Hartford, CT 06106, USAPediatric Gastroenterology, Hepatology and Nutrition, Mass General for Children, Boston, MA 02114, USAMassachusetts Eye and Ear Infirmary, Boston, MA 02114, USAPediatric Gastroenterology, Hepatology and Nutrition, Mass General for Children, Boston, MA 02114, USAChanges in pharyngeal and upper-esophageal-sphincter (UES) motor dynamics contribute to swallowing dysfunction. Children with type 1 laryngeal clefts can present with swallowing dysfunction and associated symptoms which may persist even after the initial endoscopic intervention. This study sought to characterize pharyngeal and esophageal motor function in children with type 1 laryngeal clefts who had persistent presenting symptoms after their initial therapeutic intervention. We retrospectively analyzed high-resolution esophageal manometry studies of children ≤ 18 years old with type 1 laryngeal clefts who had an esophageal manometry study performed for persistent symptoms after an initial repair. A total of 16 children were found to have significantly increased UES resting pressure, UES pre- and post-swallow maximum pressures, and duration of UES contraction during swallows in comparison to nine age-matched controls of children without pharyngeal anatomical abnormalities. There was no difference between UES residual pressures or pharyngeal dynamics between the two groups. UES resting and residual pressures did not correlate with VFFS in penetration and aspiration scores of children with type 1 laryngeal clefts status post repair. Our study is the first to identify specific changes in UES motor function in patients with type 1 laryngeal cleft post initial repair.https://www.mdpi.com/2218-273X/14/1/15laryngeal cleftupper esophageal sphincter (UES)high-resolution esophageal manometryoropharyngeal dysphagia |
| spellingShingle | Corey Baker Casey Silvernale Christopher Hartnick Claire Zar-Kessler Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair Biomolecules laryngeal cleft upper esophageal sphincter (UES) high-resolution esophageal manometry oropharyngeal dysphagia |
| title | Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair |
| title_full | Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair |
| title_fullStr | Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair |
| title_full_unstemmed | Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair |
| title_short | Upper Esophageal Sphincter Dysfunction in Children with Type 1 Laryngeal Cleft after Failed Primary Cleft Repair |
| title_sort | upper esophageal sphincter dysfunction in children with type 1 laryngeal cleft after failed primary cleft repair |
| topic | laryngeal cleft upper esophageal sphincter (UES) high-resolution esophageal manometry oropharyngeal dysphagia |
| url | https://www.mdpi.com/2218-273X/14/1/15 |
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