Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort
Background Fine particulate (fine particles with aerodynamic diameters ≤2.5 μm [PM2.5]) exposure has been associated with a risk of cardiac arrhythmias in adults. However, the association between PM2.5 exposure and cardiac arrhythmias in adolescents remains unclear. Methods and Results To investigat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.026370 |
| _version_ | 1797857436324855808 |
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| author | Fan He Jeff D. Yanosky Julio Fernandez‐Mendoza Vernon M. Chinchilli Laila Al‐Shaar Alexandros N. Vgontzas Edward O. Bixler Duanping Liao |
| author_facet | Fan He Jeff D. Yanosky Julio Fernandez‐Mendoza Vernon M. Chinchilli Laila Al‐Shaar Alexandros N. Vgontzas Edward O. Bixler Duanping Liao |
| author_sort | Fan He |
| collection | DOAJ |
| description | Background Fine particulate (fine particles with aerodynamic diameters ≤2.5 μm [PM2.5]) exposure has been associated with a risk of cardiac arrhythmias in adults. However, the association between PM2.5 exposure and cardiac arrhythmias in adolescents remains unclear. Methods and Results To investigate the association and time course between PM2.5 exposure with cardiac arrhythmias in adolescents, we analyzed the data collected from 322 adolescents who participated in the PSCC (Penn State Child Cohort) follow‐up examination. We obtained individual‐level 24‐hour PM2.5 concentrations with a nephelometer. Concurrent with the PM2.5 measure, we obtained 24‐hour ECG data using a Holter monitor, from which cardiac arrhythmias, including premature atrial contractions and premature ventricular contractions (PVCs), were identified. PM2.5 concentration and numbers of premature atrial contractions/PVCs were summarized into 30‐minute‐based segments. Polynomial distributed lag models within a framework of a negative binomial model were used to assess the effect of PM2.5 concentration on numbers of premature atrial contractions and PVCs. PM2.5 exposure was associated with an acute increase in number of PVCs. Specifically, a 10 μg/m3 increase in PM2.5 concentration was associated with a 2% (95% CI, 0.4%–3.3%) increase in PVC counts 0.5 to 1.0, 1.0 to 1.5, and 1.5 to 2.0 hours after the exposure. Cumulatively, a 10 μg/m3 increment in PM2.5 was associated with a 5% (95% CI, 1%–10%) increase in PVC counts within 2 hours after exposure. PM2.5 concentration was not associated with premature atrial contraction. Conclusions PM2.5 exposure was associated with an acute increased number of ventricular arrhythmias in a population‐based sample of adolescents. The time course of the effect of PM2.5 on ventricular arrhythmia is within 2 hours after exposure. |
| first_indexed | 2024-04-09T20:56:41Z |
| format | Article |
| id | doaj.art-a6a3238820354fc8a9a09738abc39a1e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T20:56:41Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-a6a3238820354fc8a9a09738abc39a1e2023-03-29T18:38:57ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-09-01111810.1161/JAHA.122.026370Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child CohortFan He0Jeff D. Yanosky1Julio Fernandez‐Mendoza2Vernon M. Chinchilli3Laila Al‐Shaar4Alexandros N. Vgontzas5Edward O. Bixler6Duanping Liao7Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PADepartment of Public Health Sciences Pennsylvania State University College of Medicine Hershey PADepartment of Psychiatry & Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PADepartment of Public Health Sciences Pennsylvania State University College of Medicine Hershey PADepartment of Public Health Sciences Pennsylvania State University College of Medicine Hershey PADepartment of Psychiatry & Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PADepartment of Psychiatry & Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PADepartment of Public Health Sciences Pennsylvania State University College of Medicine Hershey PABackground Fine particulate (fine particles with aerodynamic diameters ≤2.5 μm [PM2.5]) exposure has been associated with a risk of cardiac arrhythmias in adults. However, the association between PM2.5 exposure and cardiac arrhythmias in adolescents remains unclear. Methods and Results To investigate the association and time course between PM2.5 exposure with cardiac arrhythmias in adolescents, we analyzed the data collected from 322 adolescents who participated in the PSCC (Penn State Child Cohort) follow‐up examination. We obtained individual‐level 24‐hour PM2.5 concentrations with a nephelometer. Concurrent with the PM2.5 measure, we obtained 24‐hour ECG data using a Holter monitor, from which cardiac arrhythmias, including premature atrial contractions and premature ventricular contractions (PVCs), were identified. PM2.5 concentration and numbers of premature atrial contractions/PVCs were summarized into 30‐minute‐based segments. Polynomial distributed lag models within a framework of a negative binomial model were used to assess the effect of PM2.5 concentration on numbers of premature atrial contractions and PVCs. PM2.5 exposure was associated with an acute increase in number of PVCs. Specifically, a 10 μg/m3 increase in PM2.5 concentration was associated with a 2% (95% CI, 0.4%–3.3%) increase in PVC counts 0.5 to 1.0, 1.0 to 1.5, and 1.5 to 2.0 hours after the exposure. Cumulatively, a 10 μg/m3 increment in PM2.5 was associated with a 5% (95% CI, 1%–10%) increase in PVC counts within 2 hours after exposure. PM2.5 concentration was not associated with premature atrial contraction. Conclusions PM2.5 exposure was associated with an acute increased number of ventricular arrhythmias in a population‐based sample of adolescents. The time course of the effect of PM2.5 on ventricular arrhythmia is within 2 hours after exposure.https://www.ahajournals.org/doi/10.1161/JAHA.122.026370adolescentsair pollutioncardiac arrhythmiapremature ventricular contraction |
| spellingShingle | Fan He Jeff D. Yanosky Julio Fernandez‐Mendoza Vernon M. Chinchilli Laila Al‐Shaar Alexandros N. Vgontzas Edward O. Bixler Duanping Liao Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adolescents air pollution cardiac arrhythmia premature ventricular contraction |
| title | Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort |
| title_full | Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort |
| title_fullStr | Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort |
| title_full_unstemmed | Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort |
| title_short | Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population‐Based Sample of Adolescents: The Penn State Child Cohort |
| title_sort | acute impact of fine particulate air pollution on cardiac arrhythmias in a population based sample of adolescents the penn state child cohort |
| topic | adolescents air pollution cardiac arrhythmia premature ventricular contraction |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.026370 |
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